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BCBA - Board Certification in Business Valuation(R) (BCBA) - Dump Information

Vendor : Real-Estate
Exam Code : BCBA
Exam Name : Board Certification in Business Valuation(R) (BCBA)
Questions and Answers : 251 Q & A
Updated On : December 18, 2018
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BCBA Questions and Answers

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BCBA Board Certification in Business Valuation(R) (BCBA)

Study Guide Prepared by Killexams.com Real-Estate Dumps Experts


Killexams.com BCBA Dumps and Real Questions

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BCBA exam Dumps Source : Board Certification in Business Valuation(R) (BCBA)

Test Code : BCBA
Test Name : Board Certification in Business Valuation(R) (BCBA)
Vendor Name : Real-Estate
Q&A : 251 Real Questions

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Real-Estate Real-Estate Board Certification in

true property utility market set to develop based on forecasts | killexams.com Real Questions and Pass4sure dumps

This document reviews precise estate utility in world market, exceptionally in North the us, Europe, China, Japan, Korea and Taiwan, specializes in precise producers in world market, with skill, production, price, income and market share for each company, masking Intel

The record on precise estate utility market is an all-inclusive look at of the latest scenario of the business with the bottom 12 months being 2019 and its growth possibilities over 2019-2025. The file is a meticulous recreation to present a comprehensive overview of real property application market in accordance with boom alternatives and market shares.

This record offers an in-depth research about the standard state of true property utility market and tasks an outline of its growth market. It also gives the critical points of the market and throughout most important world regions in detail.

number on fundamental and secondary analysis has been conducted with the intention to compile required statistics for completing this particular document. Sever industry based mostly analytical suggestions has been narrowed down for a stronger realizing of this market.

file: www.researchnreports.com/request_sample.personal home page?id=77337

companies Profiled in this record includes    Intel

    Qualcomm

    NXP Semiconductors

    Texas contraptions

    Cypress Semiconductor

    Mediatek

    Microchip technology

    Renesas Electronics

    Stmicroelectronics

    Huawei applied sciences

    Nvidia

    advanced Micro devices

    Samsung Electronics

The development of more suitable products and multiplied affected person effects has resulted due to the competitive environment in the market.

The document covers real estate utility market from the bottom line, starting from its definition. Later, it segments the market on a lot of standards to supply a depth of knowing on the a number of product types and pricing structures and purposes.

each and every phase is examined cautiously by factoring in income, earnings and market dimension so as to have in mind the talents of boom and scope.

file: www.researchnreports.com/.Hypertext Preprocessor?id=77337

 

motive to access precise property software Market research file:

analysis of actual estate application market and its upcoming boom possibilities is been outlined with maximum precision. This look at contains an elaborative abstract of market which additionally contains snapshots that offer depth of information of a lot of other segmentations.

through qualitative and quantitative evaluation of key components which are liable for boosting or hampering the market growth and the promising alternatives in market were give. primary and secondary research is been done in aspect which helps the readers have a powerful realizing of the comprehensive market for the forecast duration.

desk of Contents

world actual property application Market analysis file

Chapter 1 true property application Market Overview   

Chapter 2 international financial have an impact on on trade   

Chapter 3 international Market competitors by using manufacturers 

Chapter four international construction, salary (price) via location

Chapter 5 international deliver (construction), Consumption, Export, Import by using regions 

Chapter 6 world construction, profits (value), fee fashion by using class   

Chapter 7 world Market evaluation with the aid of application   

Chapter 8 Manufacturing can charge evaluation   

Chapter 9 Industrial Chain, Sourcing approach and Downstream patrons   

Chapter 10 marketing approach evaluation, Distributors/traders 

Chapter 11 Market effect factors analysis   

Chapter 12 global actual property application Market Forecast

record: www.researchnreports.com/.personal home page?identification=77337

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Morguard actual estate funding have faith broadcasts CFO Transition | killexams.com Real Questions and Pass4sure dumps

No outcomes discovered, try new keyword!MISSISSAUGA, ON, Nov. 12, 2018 /CNW/ - The Board of Trustees of the Morguard true estate funding believe (the "have confidence") (TSX: MRT.UN) these days announced that it has authorized a main monetary Officer ("C...

precise property Q&A: If I change my intellect about renting a spot, can they maintain my deposit? | killexams.com Real Questions and Pass4sure dumps

Q: We were going to rent a home in a condo community. We stuffed out the application and left a $250 deposit. a number of days later, we were counseled that we had been accepted and vital to pay an extra $850 for the deposit. We went and left the assess but could not finalize the rent because the supervisor become no longer on the office. Over the weekend, we determined that we didn't are looking to appoint there and referred to as Monday to ask for our money back. they are refusing. Can they maintain our funds? — Linda

A: No, doubtless not, or at least now not most of it. i am going to use this opportunity to restate some tips that I can not appear to say satisfactory: do not signal anything unless and until you examine it and take note what it says.

in case you aren't sure what it ability, do not signal except you do. i am going to go out on a limb and count on that your initial $250 “deposit” turned into an “software price,” which you agreed to pay somewhere within the pleasant print of the multi-web page utility. If here is correct, you have got already spent those $250, and they are gone. you should review your reproduction of the kind (at all times get a copy of every thing you signal!) and confirm this. If it became a deposit and not a charge, be sure you be in a position to get it returned.

The $850 assess goes to depend upon if and what you signed in case you dropped off the assess. in case you simply left it with the workplace and did not sign the lease documents, they'll need to return your cash. despite the fact, if you signed a lease, you may be accountable in your deposit and even some hire, depending on the phrases of the contract you signed.

You may additionally have also signed, both on the time of utility or for those who dropped off the 2nd assess, a “reservation” kind that holds the unit for you until a lease is utterly signed. If here is the case, you'll should evaluation the terms of the reservation to peer when you are entitled to money back.

———

concerning the author

Gary M. Singer is a Florida lawyer and board-licensed as an authority in actual property legislation by the Florida Bar. He practices actual property, company litigation and contract legislations from his office in break of day, Fla. he is the chairman of the real property component to the Broward County Bar association and is a co-host of the weekly radio display prison news and evaluation. He commonly consults on established true estate concerns and developments in Florida with various groups throughout the nation. send him questions on-line at www.sunsentinel.com/askpro or follow him on Twitter @GarySingerLaw.

Copyright 2018 Tribune content material agency.


BCBA Board Certification in Business Valuation(R) (BCBA)

Study Guide Prepared by Killexams.com Real-Estate Dumps Experts


Killexams.com BCBA Dumps and Real Questions

100% Real Questions - Exam Pass Guarantee with High Marks - Just Memorize the Answers



BCBA exam Dumps Source : Board Certification in Business Valuation(R) (BCBA)

Test Code : BCBA
Test Name : Board Certification in Business Valuation(R) (BCBA)
Vendor Name : Real-Estate
Q&A : 251 Real Questions

Right place to find BCBA Latest dumps paper.
I exceeded the BCBA exam thanks to this bundle. The questions are accurate, and so are the subjects and take a look at courses. The format could be very convenient and permits you to examine in one-of-a-kind codecs - practising at the trying out engine, studying PDFs and printouts, so that you can exercise session the fashion and stability thats right for you. I personally loved practising on the trying out engine. It completely simulates the exam, thats especially vital for BCBA exam, with all their specific query sorts. So, its a bendy but reliable way to attain your BCBA certification. Ill be using killexams.com for my subsequent stage certification checks, too.


BCBA exam isn't any greater tough with these QAs.
The solutions are explained in short in simple language and nonetheless make pretty an impact thats clean to understand and observe. I took the help of killexams.com Q&A and exceeded my BCBA exam with a wholesome rating of sixty nine. way to killexams.com Q&A. I would really like to indicate in favor of killexams.com Q&A for the practise of BCBA examination


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Phrase of mouth is a very strong manner of advertising and advertising for a product. I say, whilst some thing is so suitable, why no longer do a little high fine publicity for it I would really like to unfold the word approximately this one in every of a kind and definitely extremely good killexams.Com which helped me in appearing outstandingly well in my BCBA examination and exceeding all expectations. I might say that this killexams.Com is one of the maximum admirable on line education ventures i have ever come across and it merits a whole lot of recognition.


What is needed to examine for BCBA examination?
that is my first time that I took this provider. I feel very confident in BCBA but. I put together my BCBA the use of questions and answers with exam simulator softare via killexams.com team.


Dumps of BCBA exam are available now.
applicants spend months looking to get themselves prepared for their BCBA assessments however for me it changed into all just a days work. youll wonder how someone would have the ability to finish this kind of super task in only a day let me inform you, all I had to do turned into sign in myself on this killexams.com and the whole thing changed into precise after that. My BCBA check seemed like a very simple challenge due to the fact i was so nicely prepared for it. I thank this web site for lending me a assisting hand.


discovered an correct source for real BCBA contemporary dumps.
I certainly asked it, honed for a week, then went in and surpassed the exam with 89% marks. that is the issue that the proper examination arrangement ought to be much like for each person! I got to be BCBA affirmed accomplice attributable to this web page. theyve an excellent accumulation of killexams.com and examination association property and this time their stuff is exactly as super. The inquiries are valid, and the examination simulator works best. No troubles identified. I suggested killexams.com Q&A Steadfast!!


What are requirements to pass BCBA examination in little attempt?
Killexams.Com substances cowl each element of BCBA , round which the BCBA exam is built. So if youre new to it, this is a need to. I needed to step up my expertise of BCBA qa has helped me loads. I exceeded the BCBA examination way to killexams.Com and had been recommending it to my friends and co-workers.


It changed into first revel in however remarkable experience!
I didnt plan to apply any mind dumps for my IT certification assessments, but being underneath strain of the problem of BCBA exam, I ordered this bundle. I was stimulated through the nice of those substances, theyre in fact worth the coins, and that i believe that theyll value greater, this is how notable they are! I didnt have any hassle even astaking my exam thanks to Killexams. I really knew all questions and answers! I got ninety seven% with just a few weeks examination education, except having some paintings enjoy, which modified into virtually beneficial, too. So sure, killexams.com is definitely properly and enormously endorsed.


in which am i able to find BCBA dumps questions?
I were given this percent and exceeded the BCBA exam with ninety seven% marks after 10 days. Im quite fulfilled via the end result. There may be extremely good stuff for associate stage confirmations, however regarding the expert level, I count on that is the precept strong plan of action for high-quality stuff, particularly with the exam simulator that gives you a danger to practice with the advent and experience of a real examination. That is a definitely substantial brain dump, authentic observe manual. That is elusive for cutting aspect exams.


where am i able to find observe guide for exact knowledge of BCBA exam?
Id advise this query bank as a should must all and sundry who is preparing for the BCBA exam. It became very beneficial in getting an idea as to what form of questions were coming and which regions to interest. The practice check provided was also brilliant in getting a experience of what to expect on examination day. As for the solutions keys supplied, it become of first rate help in recollecting what I had learnt and the explanations provided have been easy to understand and definately brought charge to my concept on the difficulty.


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Business bulletins: Lubbockites earn promotions and awards | killexams.com real questions and Pass4sure dumps

PSC promotes several in Lubbock

Parkhill, Smith & Cooper has recently promoted several design professionals from its Lubbock office.

Brandon Hartley, AIA, has been promoted to associate. He is a member of the healthcare sector and a BIM coordinator. He has been heavily involved with developing standards to help achieve a high level of equipment integration and help with facilities management through BIM software. Hartley has been with PSC for 10 years.

Michael Krusing, PE, has been promoted to associate. As a team leader in the aviation sector, he pulls from his design and construction oversight expertise to give our clients the same level of service that helped win the 2015 and 2017 TxDOT Aviation’s Most Improved General Aviation Airport of the Year. Krusing has designed multiple projects for TxDOT Aviation and New Mexico Department of Transportation. Krusing has been with PSC for nearly 11 years.

Todd Stiggins, PE, has been promoted to associate. He is a project manager for municipal solid waste in PSC’s environmental sector. His experience includes engineering design and construction services for over 150 acres of MSW landfill liner, final cover and capital improvement projects in Texas and Oklahoma, including managing project scopes, schedules and budgets in excess of $50 million. Todd has been with PSC for two years and has 15 years of experience. 

^

Galley joins local law firm

Jonathan Galley has joined the law firm of Craig, Terrill, Hale & Grantham.

The law firm specializes in civil legal matters.

Galley earned his juris doctorate from the University of Tulsa College of Law and has been licensed for seven years.

Bass named to super lawyer list

R. Byrn “Byrnie” Bass, Jr. was selected for the 2018 Texas Super Lawyer List.

Bass was recognized for his work in business bankruptcies. This is the thirteenth time he has been named to the list.

Bass is past chairman of the bankruptcy law section of the State Bar of Texas, past president of the West Texas Bankruptcy Bar Association and also past president of the Lubbock County Bar Association. In 2013 he was the recipient of the State Bar Bankruptcy Law Section’s Pro Bono Service Award. He graduated from Baylor University in 1969 and received his Law Degree from the University of Texas School of Law in 1972.

Bass also chaired the 2014 Lubbock Area United Way Campaign and currently serves on the board of directors of the Lubbock Chamber of Commerce.

^

Mears earns national recognition

Nick Mears has been nominated by the National Association of Certified Valuators and Analysts (NACVA) to the 2018 40 Under Forty program.

This program recognizes 40 individuals across the U.S. who are under 40 years old and exemplify the brightest emerging leaders in the business valuation profession.

Mears is a managing member and founder of Lubbock-based Caprock Business Consulting.

"I am honored to be part of this prestigious program and thank you NACVA for your consideration as one of the top emerging leaders in the business valuation community across the country," he said.

Submit business news to sself-walbrick@lubbockonline.com. Announcements are due Thursday at noon for Sunday publication.


Ionis Pharmaceuticals, Inc. (IONS) Q3 2018 Earnings Conference Call Transcript | killexams.com real questions and Pass4sure dumps

Logo of jester cap with thought bubble.© The Motley Fool Logo of jester cap with thought bubble.

Ionis Pharmaceuticals, Inc.  (NASDAQ: IONS)

Q3 2018 Earnings Conference Call

Nov. 06, 2018, 11:30 a.m. ET

Ionis Pharmaceuticals Inc

Contents:
  • Prepared Remarks
  • Questions and Answers
  • Call Participants
  • Prepared Remarks:

    Operator

    Good morning, and welcome to the Ionis Pharmaceuticals Third Quarter 2018 Financial Results Conference Call. As a reminder, this call is being recorded.

    At this time, I would like to turn the call over to Wade Walke, Vice President, Investor Relations, to lead off the call. Please begin.

    Wade Walke -- Vice President, Investor Relations

    Thank you, Cole. Before we begin, I encourage everyone to go to the Investor section of the Ionis website to find our press release and the related financial tables, including the reconciliation of the GAAP to pro forma financial measures that we will discuss today. We believe pro forma financial results better represent the economics of our business and how we manage our business. We have also posted slides on our website that accompany our discussion today.

    With me on the call are today are Stan Crooke, Chairman of the Board and Chief Executive Officer; Beth Hougen, Chief Financial Officer; Damien McDevitt, Chief Business Officer; and Brett Monia, Chief Operating Officer.

    I would like to draw your attention to slide three which contains our forward-looking language statement which we'll be making today, forward-looking language statements which are based on our current expectations and beliefs. These statements are subject to certain risks and uncertainties, and our actual results may differ materially. I encourage you to consult the risk factors discussed in our SEC filings for additional details.

    And with that, I'll turn the call over to Stan.

    Stanley T. Crooke -- Chairman of the Board & Chief Executive Officer

    Thanks, Wade, and good morning, everyone. Thanks for joining us. In the third quarter, we achieved a number of important milestones, and in the aggregate that results in continued financial strength for the company. We're on track for our third consecutive year of pro forma operating income, and we're doing this while launching TEGSEDI and preparing to launch WAYLIVRA.

    Our solid financial performance results from more sources of revenue including growing SPINRAZA revenue on top of our substantial base of R&D revenue from numerous successful partnerships. With the TEGSEDI launch under way, we look forward to adding commercial revenue from this drug and potentially WAYLIVRA. We expect SPINRAZA sales to continue to grow globally, given the positive new data Biogen reported from the nature study in pre-symptomatic infants.

    We also expect to see continued growth in key patient segments such as the adult patients in the US which make up 60% of the SMA population, with only a fraction of those patients now being treated. Positive impact of SPINRAZA has now been recognized with several Prix Galien awards around the world, and was also recently recognized again by the scientific community with the awarding of the breakthrough prize in life sciences to Frank Bennett, our SVP of Research and Head of Neurological Disease Franchise. Frank shared this honor with Dr. Adrian Krainer of Cold Spring Harbor Laboratory.

    The TEGSEDI launch is now under way in multiple countries, and we and our affiliate Akcea are encouraged by the continuing enthusiasm we are seeing from the amyloidosis community for this drug with strong team, the necessary infrastructure and global strategy in place, we are confident in Akcea's ability to successfully launch TEGSEDI.

    With WAYLIVRA, we and Akcea are in active discussions with EMA, and we continue our conversations for path forward with the FDA. All of these review processes are progressing.

    Our EAP program is going well, and we continue to work to bring all the patients with FCS, the first-ever treatment of this ultra-rare, debilitating and potentially fatal disease. In the Phase 2 study of AKCEA-APO(a)-LRx, the drug demonstrated substantial dose-dependent reductions in a Lp(a) in patients with established cardiovascular disease and elevated Lp(a). We also observed the favorable safety and tolerability profile. We're very encouraged by the drug's performance using convenient low-volume monthly doses.

    We and Akcea, along with our partner Novartis, now have what we need to select a dose and advance the drug into a large cardiovascular outcome study to demonstrate the cardiovascular benefits of lowering Lp(a), genetically validated driver cardiovascular disease affecting millions of patients worldwide. Phase 2 study of APO(a)-LRx is the largest and the longest study of a LICA drug today, with nearly 300 patients dosed up to 12 months.

    Robust target reduction and favorable safety and tolerability profile observed in this study adds to our confidence in the potential of LICA drugs to treat a broad range of diseases with convenient dosing regimens.

    Roche expects to initiate the Phase 3 program for IONIS-HTTRx in patients with Huntington disease before the year-end, including a pivotal study and a natural history study. Building on our successful relationship with Roche, we entered a new collaboration to the development of Ionis factor B LRx. For the treatment of patients with a broad range of complement-mediated diseases beginning with geographic atrophy, the advanced stage of dry age-related macular degeneration.

    We believe Roche is the right partner to maximize the potential for success of this program, and the substantial level of participation we retain in the drug's commercial success is another example of the strong value of our antisense platform.

    Beyond these important highlights, we've had numerous other pipeline achievements which not only contribute to our significant financial strength, but more importantly show that important new drugs we are advancing closure to patients who desperately need it. Our focus remains on delivering innovative new medicines to patients in need, while positioning the company for continued growth.

    I'll now turn the call over to Beth.

    Elizabeth L. Hougen -- Senior Vice President, Finance & Chief Financial Officer

    Thank you, Stan. Good morning, everyone. We ended the first nine months of 2018 with operating income of $25 million and net income of $51 million, both on a pro forma basis. Our strong financial results were driven by double-digit revenue growth compared to the same period in 2017, a nearly threefold increase in commercial revenue from SPINRAZA royalties compared to the first nine months of 2017 together with a substantial base of R&D revenue were key factors contributing to our financial performance this year. Additionally, we ended the third quarter with approximately $2 billion in cash.

    With TEGSEDI now launched in multiple countries, and a catalyst-rich next six months, we are positioned for continued financial success. We project our fourth quarter results will be driven by growth in commercial revenue from SPINRAZA royalties as global sales increase. Last quarter, we moved into the highest royalty tier which means we earn a greater share of each dollar of SPINRAZA sales. In addition, we expect TEGSEDI product sales to contribute to our commercial revenue growth in the fourth quarter.

    We also project our fourth quarter R&D revenue to increase due to the amortization of the $75 million upfront payment from our new collaboration with Roche for our FB program. And already this quarter we have earned two milestone payments from AstraZeneca, totaling nearly $30 million for advancing two different programs.

    We are on track to easily meet our guidance of pro forma operating income even while investing in the launch of TEGSEDI and preparing to launch WAYLIVRA. We are projecting to end the year with more than $1.8 billion in cash making us cash accretive for six out of the last seven years. We plan to use our cash to continue to advance and expand our pipeline including growing our pipeline of Ionis-owned drugs.

    Worldwide SPINRAZA revenues grew to $468 million driven by quarter-over-quarter and year-over-year revenue growth in the US and even greater revenue growth outside the US. Notably, year-to-date SPINRAZA global revenues surpassed $1 billion in the third quarter. The number of patients being treated with SPINRAZA increased by approximately 20% from the second quarter of 2018 and now nearly 6,000 patients are on SPINRAZA including in the EAP and clinical studies.

    In the US, more than 50% of new start forms in the third quarter were for adult patients, driving a greater than 20% increase in a number of US adult patients on SPINRAZA compared to the second quarter of 2018. Adult patients represent the largest SMA patients segment accounting for approximately 60% of the prevalent SMA patient population. However, only about 15% of these patients are receiving SPINRAZA today, representing a significant opportunity for growth.

    Revenue growth outside the US was meaningful as the pace of reimbursement increased particularly in Europe, Asia Pacific and Latin America. We expect revenue growth outside the US to continue in the fourth quarter of 2018 as the number of patients on treatment increases. That growth combined with stability in US SPINRAZA revenue in the fourth quarter compared to the third quarter of this year should result in increased royalty revenues from SPINRAZA which are nearly all profit.

    R&D revenue for numerous drugs and numerous successful collaborations continues to be a significant component of our total revenue. So far this year, we have earned more than $225 million in R&D revenue, which does not include the nearly $30 million in milestone payments we've earned so far in the fourth quarter. R&D revenue is a significant and sustainable source of revenue for us, which is why we include this source of revenue in our valuation model.

    As I discussed last quarter, our R&D revenue consists of four key components: amortization of upfront payments; milestone payments, which represents progress in our existing partnerships; license fees which represents new transactions and partner's advancing existing program and services we provide to our partners.

    Through the end of September, we had recognized $92 million of revenue from amortization and one significant component of this is in the third quarter with $14 million for the first full quarter of amortization for our new Biogen collaboration. We recognized $45 million in the first nine months of this year in milestone payments. Two significant milestone payments in the third quarter were $10 million from AstraZeneca when they initiated a Phase 1 study for the first drug in our cardiometabolic collaboration, and $10 million from Biogen when we initiated a Phase 1/2 clinical study evaluating our second drug to treat patients with ALS.

    We earned $64 million in R&D revenue during the first nine months of this year from license fees, primarily from AstraZeneca earlier in the year. This does not include the $12 million license fee we earned from the new collaboration with PTC to commercialize TEGSEDI and WAYLIVRA in Latin America, which we include in our commercial revenue. Finally, we earned $25 million from services we provided to our partners, primarily for manufacturing commercial and clinical supplies for them.

    Looking ahead, we expect our R&D revenue to grow based on three factors: an increase in the number of partnerships, an increase in partnered program and larger payments as partnered programs advance.

    Let me give you some examples. First, our R&D revenue increases as the number of collaborations we have increases. We recently entered into a second collaboration with Roche. Under this collaboration, we received a $75 million upfront payment. Together with Roche, we will be conducting a Phase 2 study in patients with geographic atrophy. Therefore, we will be amortizing the upfront payment over the course of the study beginning in the fourth quarter. We currently have 13 collaborations with large pharmaceutical companies, a number that has more than doubled over the last six years.

    Second, we are progressing more and more programs under our successful collaboration. For each program we advance, we are eligible to earn milestone payments and license fees. We currently have 22 partnered programs, a number that has nearly tripled since 2012. In 2012, we earned $51 million of revenue related to license fees and milestone payments. That's compared to over $135 million in license fees and milestone payments we have earned so far this year.

    Third as our partnered programs advance, the dollar amount we earn for milestone payments and license fees increases, reflecting the increase in value of the advancing program. For example, when we initiated the Phase 1/2 study in Huntington's patients, we received a $22 million milestone payment from Roche to help fund our cost to conduct the study. When Roche doses the first patient in the pivotal study, we will earn a $35 million milestone payment. Importantly, the $35 million will be all profit to us since Roche will be conducting the study.

    In summary, we are sustainably profitable and cash accretive with a manageable expense structure. Our growing commercial revenues together with our substantial base of R&D revenue, positions us to finish 2018 in a strong financial position and sets us up for growth in 2019.

    With that, I'll turn the call over to Damien to provide a commercial update.

    Damien McDevitt -- Chief Business Officer

    Great. Thank you, Beth. Good morning, everyone. While it is early days in the TEGSEDI launch, we are pleased with the progress the Akcea team is making to get TEGSEDI to the patients in need in the US, EU and Canada. While we are not providing sales guidance today, we and Akcea will keep you updated on how the launch is going.

    TEGSEDI was recently approved in the US with a broad label for treatment of polyneuropathy of hATTR amyloidosis in adults, regardless of stage of disease. Akcea's patient support program has launched and is enrolling patients.

    AKCEA CONNECT was built to support patients through every step of their treatment journey, dedicated nurse case managers guide patients in establishing their monitoring routine as part of the REMS program, help navigate insurance coverage options, provide home injection training and more. And together with Akcea's lab service partner Quest, patients have the option for at-home services.

    Akcea's US field team is making good progress in connecting with treating physicians and we are pleased that the first prescriptions have been received. In addition, the TEGSEDI market access team is well along with their efforts to partner with payors. Importantly, the team is working with those payors who cover the majority of lives in the US to develop the strategy that best fits the goals and the patient population they serve while ensuring that financial barriers did not negatively impact patients in need.

    Akcea's specialty pharmacy Accredo has experienced in supporting this unique need of rare disease communities helping to simplify access to therapy. Today, Accredo has been certified into the REMS program and is ready to assist patients. Accredo has a team of specialty clinicians, pharmacists, and over 600 field-based nurses located throughout the US, who will augment the Akcea connect team of nurse case managers to provide support and address the needs of the hATTR community.

    In Germany, patients are now receiving TEGSEDI in the commercial setting. Akcea's goal is to ensure that patients who need TEGSEDI have access to this. To accomplish this goal, Akcea is working to make TEGSEDI available to patients across numerous countries in the EU as quickly as possible. Additionally, Akcea Connect is rolling out in the EU to provide the optimal level of support for patients in each country.

    In Canada, Akcea Connect is in place and we look forward to delivering the first drug to treat polyneuropathy caused by hATTR amyloidosis to these patients.

    Given TEGSEDI's robust efficacy and simple self-administration, we believe TEGSEDI will be the treatment of choice for people with hATTR and their physicians. Beyond the US, EU and Canada, we and Akcea look forward to PTC Therapeutics moving TEGSEDI forward in Latin America. We are also looking to expand beyond these initial regions as part of our strategy to enable global access to TEGSEDI.

    This weekend, at the International Society for Pharmacoeconomics and Outcomes Research meeting, Akcea is presenting more detailed analysis from the neuro TTR study demonstrating TEGSEDI's positive impact on patient's quality of life. These analyses look at TEGSEDI's effect on patient's ability to complete day-to-day activities, as well as positive changes in physical and mental health.

    Now turning to WAYLIVRA. In the EU, our review process is ongoing. In the US and Canada, we plan to work with regulators to confirm a path forward. As Akcea continues to work to bring the first ever treatment to patients with FCS, the EAP program is ongoing and Akcea is prepared to launch in the EU as quickly as possible assuming approval. In addition, Akcea is making progress with patient identification with a focus on diagnosis which provides support for our estimate of 3,000 to 5,000 FCS patients worldwide.

    Now, over to Brett, to review key highlights from our pipeline.

    Brett P. Monia -- Chief Operating Officer and Senior Vice President, Translational Medicine

    Thanks, Damien. So, we achieved several additional successes since our second quarter update that I'll now review briefly, and we look forward to providing a detailed update at our Investor Day next month. Biogen recently provided an exciting update from the NURTURE study in pre-symptomatic infants with SMA. As of May 2018, all patients in this study were alive without the need for permanent ventilation, all were sitting independently, and nearly all were able to walk. And importantly, every participant in this study has continued to make progress and achieved milestones more consistent with normal development.

    These long-term data provide further evidence that early diagnosis of SMA in treatment with SPINRAZA can fundamentally alter the course of this disease for pre-symptomatic infants and adds to the body of evidence supporting SPINRAZA as it would be standard of care for all patients with SMA.

    Shifting gears a bit, in the Phase 2 study of AKCEA-APO(a)-LRx, patients with established cardiovascular disease in elevated Lp(a) levels achieved dose-dependent reductions in Lp(a) with most patients in the active group attaining levels below the established threshold of risk for cardiovascular disease. Additionally, APO(a)-LRx demonstrated a favorable safety and tolerability profile consistent with our other LICA drugs. As is well documented, elevated Lp(a) levels is a driver of cardiovascular disease that affects millions of people worldwide. It cannot be controlled with lifestyle modifications such as diet or exercise, and there are no approved therapies that specifically target and reduce Lp(a) levels.

    The Ionis and Akcea team with our partner Novartis are now preparing for an end-of-Phase 2 meeting with the FDA followed by the potential initiation of a large cardiovascular outcome study which will be designed to demonstrate the cardiovascular benefits of lowering Lp(a) levels in patients with established cardiovascular disease. Novartis, of course, is highly experienced in conducting large CV outcome studies, and they have been actively preparing to initiate the study once they exercise their option.

    And importantly with royalties up to the low 20% range, we retain significant value in the commercial success of the drug. We look forward to presenting additional data from the Phase 2 study this Saturday at AHA and at our Investor Day next month.

    Shifting attention, our partner AstraZeneca recently reported positive Phase 2 data for danvatirsen, our STAT3 inhibitor at this year's ESMO conference. In combination with durvalumab, AstraZeneca's PD-L1 blocking antibody in recurrent metastatic head and neck cancer treatment resulted in 7% of patients achieving a complete tumor response and 23% achieving either a partial or a complete tumor response. This response rate is estimated to be double that of durvalumab alone, based on previous studies in this difficult to treat patient population.

    And our partnership with Roche continues to go well also. Roche announced the study design for the IONIS-HTTRx pivotal program which they plan to initiate before the end of the year. Working closely with regulators, Roche has designed a highly innovative pivotal study to generate a robust data set. We get this important medicine to people with Huntington's disease as rapidly as possible.

    The program will include two studies with patients beginning to enroll by early 2019. The first study is a Phase 3 study which will be the world's first to measure the effect of a drug that will directly reduce the amount of the protein that causes Huntington's disease in patients. This three-year study will evaluate long-term safety and efficacy in up to 660 symptomatic Huntington's disease patients around the globe.

    The second study is a 15-month natural history study in up to 100 symptomatic patients designed to further our understanding of the correlation between changes in new huntingtin protein and clinical measures.

    As a reminder, IONIS-HTTRx is the first and only drug to demonstrate a substantial lowering of the new huntingtin protein (inaudible) in clinical benefit in patients with Huntington's disease which together support the drug's potential to slow or perhaps half disease progression.

    As Stan mentioned, we've recently built upon our successful relationship with Roche with a new collaboration for the development and commercialization of Ionis FPL or actually for the treatment of people with a broad range of complement-mediated diseases beginning with geographic atrophy, the advanced stage of dry AMD.

    As a reminder, for each product in our pipeline, we see the commercialization strategy that maximizes the drug's commercial success while optimizing our participation in that success. When partnered with IONIS-FB-LRx requesting for development of drugs for renal disease and particularly geographic atrophy is complex and requires specialized experience.

    Roche has a substantial development infrastructure and experience in developing and commercializing medicines for renal diseases. Furthermore, Roche is prepared to pursue additional complement mediated disease indications well-suited for IONIS-FB-LRx. Importantly, with royalties of up to 20% we participate substantially in the commercial success of this drug. And in the coming months, we look forward to showing more of the data we have generated from our LICA programs, our other LICA programs, in clinical studies, and publishing the full integrated safety database for these LICA drugs which are performing exceptionally well.

    In clinical studies, our LICA drugs had demonstrated increases in potency of 30-fold or greater enabling low volume and less frequent dosing. We've also reserved good safety and tolerability potent target production. These results are consistent with those observed in the Phase 2 study of our APO(a)-LRx drug in nearly 300 patients treated for up to a year. Finally, we have had many additional achievements since our second quarter update. We completed our enrollment of a Phase 2b study of IONIS-FactorXIRx in patients with end-stage renal disease on dialysis and initiated a Phase 1 study of the LICA version IONIS-FactorXI-LRx both with data expected in the second half of 2019.

    AstraZeneca initiated a Phase 1 study of our first generation 2.5 LICA drug to enter the clinic IONIS-AZ4-2.5-LRx, which is one of the three drugs in development under our highly productive cardiometabolic renal disease collaboration with AstraZeneca. And Biogen initiated a Phase 1/2 study of IONIS-C9Rx, our second familial ALS drug which is in addition to IONIS-SOD1Rx, which is in a Phase 1/2 study in familial ALS and patients with SOD1 mutation with data expected in Q1 2019.

    As shown on this slide, we successfully completed many key milestones this year. In the fourth quarter and into 2019, we're looking forward to numerous important catalysts including several regulatory decisions, data readouts and study initiations. We also look forward to discussing many of these events at our Investor Day in December.

    And now, I will turn the call back over to you, Stan.

    Stanley T. Crooke -- Chairman of the Board & Chief Executive Officer

    Thank you, Brett. So, the third quarter was another very strong quarter for the company. We continue to demonstrate the power of the financial model that we built with continuing financial strength even while launching TEGSEDI and preparing the launch of WAYLIVRA. So, we are -- we continue to be substantially profitable and we believe we are positioned for continued growth.

    We believe WAYLIVRA demonstrates a positive benefit/risk profile for patients suffering with FCS with no therapeutic options. Regulatory process continued in the EU, and we are in conversations with the FDA and Canadian authorities as well. Akcea is ready to launch WAYLIVRA as quickly as possible once we have approval in the EU and other territories.

    We have a number of near-term value drivers including plans to initiate at least three pivotal studies before the end of the year. These are programs with the potential to change of course fatal genetic diseases, such as Huntington's disease, TTR amyloidosis, as well as diseases that affect millions of patients such as Lp(a) driven cardiovascular disease. We also have multiple mid-stage programs in a number of therapeutic areas that we're excited about which have the potential to drive longer-term growth. We look forward to discussing more about these programs as they progress.

    With that, I'll turn the call over to Cole to set us up for Q&A. Cole, would you please set us up?

    Questions and Answers:

    Operator

    Certianly. We will now begin the question-and-answer session. (Operator Instructions) Our first question comes from Tyler Van Buren with Piper Jaffray. Please go ahead with your question.

    Tyler Van Buren -- Piper Jaffray -- Analyst

    Good morning, guys. Thanks for taking my question. I guess, the first one was with respect to the TEGSEDI REMS program, specifically regarding logistics for docs who aren't I guess as familiar with the REMS programs how easy is it going to be for them to sign up? What specifically do they have to do? How are you guys helping them? And how long could that take? I noticed that some of the questionnaires online are actually quite simple with less than 10 questions, but just wanted to better understand that process.

    Damien McDevitt -- Chief Business Officer

    Yes. So, thank you for your question, Tyler. So, this is why we've set up Akcea Connect to help physicians and patients work through the paperwork associated with the REMS program. So, as you spotted, it's very straightforward going through these paperwork. And to date, there's been no issues. We've had physicians and patients certified through REMS and registered on Akcea Connect.

    Stanley T. Crooke -- Chairman of the Board & Chief Executive Officer

    Just to add to that Tyler, I actually went through the process myself, and so there was a lot of effort at reducing the burden everywhere on the patient, on the physician and the physician's office. And so I feel very, very uncomfortable with how easy it is to enroll in the program that Akcea has put together. I think it's quite an exciting advance in managing these processes.

    Tyler Van Buren -- Piper Jaffray -- Analyst

    That's great. Are you able to say how many doctors are certified on the REMS or how many patients are on the REMS?

    Damien McDevitt -- Chief Business Officer

    No, we're not providing numbers. We have had patients and physicians certified to-date, but we're not giving out the exact numbers at this point.

    Stanley T. Crooke -- Chairman of the Board & Chief Executive Officer

    We're encouraged by what received. We're encouraged by what received.

    Tyler Van Buren -- Piper Jaffray -- Analyst

    Okay. And the second question was with respect to the platelet monitoring. I guess, I'm assuming that the samples need to be taken by a nurse and that the patient can't do it themselves, or maybe you can correct me if I'm wrong, but specifically and logistically, how will it happen? How long will it take? And if someone is on a business trip how would you get their platelet levels monitored on a weekly basis?

    Damien McDevitt -- Chief Business Officer

    So, the patient -- the platelet monitoring will happen, the blood draws will be done at home, and with nurses, and so does that help.

    Stanley T. Crooke -- Chairman of the Board & Chief Executive Officer

    So, platelet monitoring is designed so it will be as convenient as possible. We'll go where the patient wants us to go. The patient is near a lab and they prefer going in and getting their blood drawn there. Great if they are traveling, why, of course, there are clinical laboratories everywhere, (inaudible) so that the patient can go there and get the job done. And of course we're providing the opportunities to have the platelets determined or blood drawn in, in the home as well. At least, once a week, it's over in a matter of just a couple of minutes. It's rapid easy. Certainly, speaking for myself, I would rather do that and go to an infusion center and spend a day getting an IV infusion.

    Tyler Van Buren -- Piper Jaffray -- Analyst

    Yes. And that makes sense. I guess if you're having nurses go to the patient's home or if they're on a business trip and wherever location they are, don't you guys have to have a lot of nurses on staff or be plugged into some large network? Just I guess curious to hear a little bit about that.

    Damien McDevitt -- Chief Business Officer

    Yes. So, when we are plugged into the large network and through Accredo, there are 600 nurses on staff throughout the US. So that's fairly large network available.

    Stanley T. Crooke -- Chairman of the Board & Chief Executive Officer

    And Quest. Of course, we have a partnership with Quest, so that there's a lab. It's not Starbucks, but it's almost Starbucks, except the lines are shorter.

    Tyler Van Buren -- Piper Jaffray -- Analyst

    Great. Thanks a lot for taking the questions.

    Stanley T. Crooke -- Chairman of the Board & Chief Executive Officer

    You bet.

    Operator

    And our next question comes from Paul Matteis with Stifel. Please go ahead with your question.

    Ben Burnett -- Stifel -- Analyst

    Hi. Thank you. This is Ben Burnett on for Paul Matisse. Just a question on the SOD1 program, the upcoming readout here. Can you discuss what level of knockdown you would constitute as sufficient as supportive of advancing the program? And then I guess secondly, are you able to speak to the level of enrollment to the extension study? And I guess, can you just remind us of the regulatory path forward for this assuming positive data in 2019? Thank you.

    Brett P. Monia -- Chief Operating Officer and Senior Vice President, Translational Medicine

    Yes. This is Brett. I will take that call -- that question. So, as I think you inferred, we can measure SOD1 levels. We validated SOD1 levels in the CSF much like we did for the Huntington program, where we were able to demonstrate market reductions in the CSF for Huntington. So that will be part of the clinical study. It's a three-month study in patients with symptomatic ALS with SOD1 mutations. And based on a pre-clinical data, we can -- that reductions on the order of 30% to 50% much like Huntington have shown significant benefit in animal models of SOD1 ALS. In fact those types of reductions have shown complete halting of disease progression in SOD1 animal models.

    Regarding the study, the study is enrolled. And we're looking at data readout in the first quarter of next year. And as for regulatory path, it's hard to say, how we see the data. But as I mentioned, the study design is very similar to the Huntington study. And as you know, the Huntington study went from Phase 1 to pivotal Phase 3 study. So, it's not outside the wrong possibility that based on the data that comes out, Biogen would move in that direction.

    Ben Burnett -- Stifel -- Analyst

    Thanks Brett.

    Wade Walke -- Vice President, Investor Relations

    Next question please.

    Operator

    And our next question comes from Chad Messer with Needham & Company. Please go ahead with your question.

    Chad Messer -- Needham & Company -- Analyst

    Great. Thanks. Thanks for taking my question. I have one on danvatirsen, the STAT3 program. What can we expect from that next maybe in terms of other indications? And any idea when that might join the ranks of Phase 3 along with some of the other programs?

    Brett P. Monia -- Chief Operating Officer and Senior Vice President, Translational Medicine

    Thanks, Chad. So, thanks for the question. Yes, our immuno-oncology program -- our oncology program in general is really showing a lot of great potential. Our STAT3 leads the way. It was our first-generation 2.5 molecule to enter the clinic. And we've recently with AstraZeneca recently reported very encouraging results as I highlighted in the script in the presentation we just gave in patients with refractory head and neck cancer in combination with durvalumab. That study -- that drug in that combination has also now started a steady non-small cell lung cancer, so that's another indication to your question, and bladder cancer. And AstraZeneca is exploring other oncology indications produced for this program.

    AstraZeneca is collecting more and more data in this study, in the second line refractory study, as well as in first line head and neck cancer patients in combination with durvalumab. And over the next few months, they're planning to make a decision on the next stage of development for the program in the head and neck cancer which could certainly be a pivotal study.

    Chad Messer -- Needham & Company -- Analyst

    Thanks, Brett.

    Operator

    And our next question comes from Gena Wang with Barclays. Please go ahead with your question.

    Gena Wang -- Barclays -- Analyst

    Thank you for taking my questions. One question regarding SPINRAZA, I know the World Muscle, NURTURE data was very impressive. Just wondering what will be the next step to expand label to the pre-symptomatic patients? And then a very quick question regarding the WAYLIVRA, any plan for the FDA regulatory path for the next step?

    Stanley T. Crooke -- Chairman of the Board & Chief Executive Officer

    Thanks. The SPINRAZA label supports administration of SPINRAZA to patients of any sort with SMA. And certainly more and more babies are being treated presymptomatically because the data are so overwhelmingly positive. So that's happening as we speak.

    Damien McDevitt -- Chief Business Officer

    And, of course, just to add to that Stan, as you know Gena, the newborn screening has incorporated now officially nationally SMN2 as a genetic measurement in the newborn screen panel to identify the patients that are presymptomatic that will develop SMA. And now that's becoming incorporated into a statewide system and nationally as well. So all this bodes very well for treating more and more patients presymptomatically both the genetic testing as well as the data, the NURTURE data that was presented in World Muscle.

    Stanley T. Crooke -- Chairman of the Board & Chief Executive Officer

    The other thing that's sort of been forgotten, but it's tremendously impressive to me is that it's not just in the NURTURE study that we see would continue to -- treatment patients continue to get better and better. We're seeing the same sort of behavior in less severe infants and infants that are treated asymptomatically and we're seeing it in the type two and the adult patients as well. So, today SPINRAZA has delivered incredible value. And the longer we treat, the better it is for essentially all the patient types that have been treated with SPINRAZA. So, it looks quite exciting.

    Wade Walke -- Vice President, Investor Relations

    Next question.

    Operator

    Our next question comes from Jessica Fye with JP Morgan. Please go ahead with your question.

    Jessica Fye -- JPMorgan -- Analyst

    Great, and thanks for taking my questions. Can you help us think about when we could see extension data from the Huntington's Phase 1/2 trial? I think clinical trials like I've said it's 14 months of treatment with completion in December of 2019. Is it possible we could see incremental update sooner given that it's open label? Also can you talk to the dose levels and dosing frequency in that extension trial?

    Brett P. Monia -- Chief Operating Officer and Senior Vice President, Translational Medicine

    Sure, Jess. Roche is not -- well the open label extension study is going very well. All the patients are obviously enrolled into the study, and they're in the study. They are continuing to be treated, and it's going well as I said. Roche has been very transparent, and has worked very closely with patient advocacy, patients, doctors, physicians, and has been very transparent in the information they've provided. They haven't said specifically when and in what cadence they're going to actually share data from the open label extension, but we believe that they'll be sharing data over the course of 2019 because it's so important to the patient community to share that data and know how the program is going. The dosing is the same as it was in Phase 1/2 which is monthly dosing, and they're administering the top dose and that was from the Phase 2 study.

    Jessica Fye -- JPMorgan -- Analyst

    Okay. And apologies, if I missed this, but for the two-year Phase 3s for that product, what specifically will be the primary clinical efficacy endpoint?

    Brett P. Monia -- Chief Operating Officer and Senior Vice President, Translational Medicine

    So the clinical endpoints are now -- have been disclosed by Roche. They're going to involve both cognitive measures, motor function measures, autonomic (ph) measures of neurological functions as well as MRI scans of brain size, and those sorts of things, quality-of-life measures. It's a composite scoring system that we're using in US and EU. It is slightly different in US and EU, and but it's now been fully vetted through the FDA, the EMA and it's been posted.

    Jessica Fye -- JPMorgan -- Analyst

    Okay. Great. And last one for me is just Novartis made some comments yesterday that they are not especially focused on combining splice modulators with gene therapy and SMA. So just curious as the leader in SMA what was your reaction to that view?

    Stanley T. Crooke -- Chairman of the Board & Chief Executive Officer

    Well, we are leaders in SMA, and we do think that there are opportunities in the future to use a variety of agents in combination. Whether a gene therapy agent would add any value to SPINRAZA given the results that we have is hard for me to know today. So, we're watching the progression of the gene therapy as well as small molecule. And if there appears to be some spot in which SPINRAZA doesn't bring sort of remarkable value, I'm sure, that Biogen and others will look at combinations. There's nothing to preclude any combination with any of the drugs that are in development that we're aware of.

    Jessica Fye -- JPMorgan -- Analyst

    Okay, great. Thank you.

    Operator

    And our next question comes from Jim Birchenough with Wells Fargo. Please go ahead with your question. Mr. Birchenough (multiple speakers).

    Yanan Zhu -- Wells Fargo -- Analyst

    Yeah. Sorry about that. Thanks. This is Yanan in for Jim. So first question regarding SPINRAZA revenues, could you describe the driver for the growth? Is it patient number or some other factors such as change in the early patients building schedule versus longer intervals in previously enrolled patients? So, any color on that?

    Stanley T. Crooke -- Chairman of the Board & Chief Executive Officer

    It's patient numbers. There hasn't been any change in dosing schedule. So what's happening is that more patients are being treated, and the patients that have been treated are continuing to be treated. So it's -- I think just correlates with benefit. More patients are being treated and more patients are being treated longer.

    Yanan Zhu -- Wells Fargo -- Analyst

    Got it. And you described an increase in adult patients. Would you be able to comment whether the pediatric patients whether that portion of the market is stable? Yeah.

    Stanley T. Crooke -- Chairman of the Board & Chief Executive Officer

    It continues to grow.

    Yanan Zhu -- Wells Fargo -- Analyst

    Got it. And you were just talking about the combinations -- potential combination the possibility with gene therapy between SPINRAZA and gene therapy. I thought Novartis mentioned a price tag of $4 million to $5 million for their gene -- potentially for their gene therapy. How does that -- what's your view on that, and how might that impact the ability to combine the two drugs?

    Damien McDevitt -- Chief Business Officer

    Well, I think it's early days. And I think I'll let Novartis discuss their pricing and its impact on whether patients of sort uses drug, and whether -- would make sense to combine it. At that price obviously any combination would have to show an extraordinary benefit compared to SPINRAZA. That's going to be very difficult to do given the fact that the vast majority of presymptomatic patients who were treated are developing like normal children. How do you do better than that?

    Yanan Zhu -- Wells Fargo -- Analyst

    Got it. And the last question on the Huntington's disease trial -- Phase 3 trial design by Roche. Would you be able to comment on whether the Phase 3 study the 660-patient study would that be a controlled or uncontrolled study?

    Damien McDevitt -- Chief Business Officer

    It's 660 and it's a controlled study, yes.

    Yanan Zhu -- Wells Fargo -- Analyst

    Got it. Thank you.

    Operator

    And our next question comes from Vincent Chen with Bernstein. Please go ahead with your question.

    Vincent Chen -- Bernstein -- Analyst

    Great. Thank you very much for taking the question. So, I guess, one question about SPINRAZA and sort of the future of the SMA market, how are you and your partners with Biogen thinking about defending against Roche's oral compound in SMA for example whether that's next-generation agents with profiles building up with the SPINRAZA and trying to demonstrate areas of potential superiority whether with SPINRAZA or follow-on potentially using the novel biomarkers, et cetera? Could you just provide us with more color on how you think about a market defense strategy here?

    Stanley T. Crooke -- Chairman of the Board & Chief Executive Officer

    Well, I think the first order of business is to continue to learn more about SPINRAZA. And today the more we learn the better the drug appears to be in all patients. Second, of course, we are collaborating with Biogen to look at a new -- various follow-ons to SPINRAZA that might have lower doses or might have less frequent dosing. I think it's -- what I think needs to happen now, before we comment on whether oral agents might be used, might be used in combination and how they might be used is one to watch how SPINRAZA does over the next year. We continue to watch that. And then second, to evaluate these -- the clinical trials that are in progress both in terms of benefit and safety. I think, there's not very much yet really know about the small molecule drugs and we're looking forward to seeing the data.

    Vincent Chen -- Bernstein -- Analyst

    Thank you.

    Operator

    And our next question comes from Ritu Baral from Cowen. Please go ahead with your question.

    Ritu Baral -- Cowen & Company -- Analyst

    Hi, guys. Thanks for taking the question. Going back to the Huntington's endpoint, the Phase 3 endpoint that we were talking about before, I think you guys mentioned, it was a composite cognitive motor functions autonomic, MRI volume and quality of life. How are those weighted within the composite? Is there any requirement for one element to show certain threshold effect for that composite endpoint to be positive? How does that primary endpoint work?

    Damien McDevitt -- Chief Business Officer

    Yes. Ritu, we will have to -- I don't have those details in front of us on how the various components to the composite score are weighted. Why don't we get back to you on that?

    Ritu Baral -- Cowen & Company -- Analyst

    Sure. And then a quick follow-up on WAYLIVRA in Europe. Can you remind us where you are on that process? Have you received like the 120-day questions as they progressed -- as there have been progress made between 120 and 180 days? Any details that you can share?

    Damien McDevitt -- Chief Business Officer

    We're late in the process. We do -- we've had a number of meetings and conversations and responses to a variety of questions 120-day and others. So we're late in the process and we're looking forward to bring it to a conclusion here in the next quarter.

    Ritu Baral -- Cowen & Company -- Analyst

    Got it. And apologies if I just wasn't writing fast enough here. You do have commercial patients on TEGSEDI. I know you have German commercial patients treated. Do you have US commercial patients treatment already started? Or is that going to be imminent given accretive just got it licensed?

    Damien McDevitt -- Chief Business Officer

    Yes. Thanks, Ritu. We have patients and physicians that are certified through REMS and registered on Akcea Connect. And we have specialties -- our specialty pharmacy certified through REMS as well and is up and running. And we have meetings with physicians and their teams and we received the first set of scripts. That's where we are today.

    Ritu Baral -- Cowen & Company -- Analyst

    Got it. Okay. That's helpful. And then I guess last question is -- sorry, the end of Phase 2 meetings that you and Novartis will have on Lp(a), given that we're all expecting just sort of a really plain vanilla boring endpoint Phase 3. Are there other topics to discuss any aspect of the compound or Lp(a) that are worth noting outside just the pure relatively boring Phase 3 time?

    Brett P. Monia -- Chief Operating Officer and Senior Vice President, Translational Medicine

    That's the first time I've heard an outcome study described as relatively boring, but OK. We're kind of excited about it, and I think, I'll just leave it there. It's a good question, but it's a little more detailed than I think would be appropriate to go into here. I'm sure that once we have the meeting that we have to discuss all that in a little more detail. I will encourage everyone to make the late-breaker that's coming this Saturday that Sam Tsimikas is presenting. We're really, really excited about the data we have to share both in terms of the potency of the agent as well as the safety tolerability. And so we look forward to being able to share much more detailed data with the community.

    Ritu Baral -- Cowen & Company -- Analyst

    Got it. Thanks for taking all the questions.

    Brett P. Monia -- Chief Operating Officer and Senior Vice President, Translational Medicine

    You bet.

    Operator

    And our next question comes from I-Eh Jen with Laidlaw & Company. Please go ahead with your question.

    Yale Jen -- Laidlaw & Company -- Analyst

    Thanks a lot for taking the questions. And I think a lot have been answered, I've got two here. The first one is that for the NASH you have two data releases later both regarding the NASH. One is the DGAT2 and the other is the ANGPTL3. Could you differentiate the specific indications that these two drop may have a target.

    Stanley T. Crooke -- Chairman of the Board & Chief Executive Officer

    Yes, that is a very interesting question. We have quite a pipeline of different agents focused on either the lipid component of NASH or the fibrotic component of NASH or all the above. The way I think of DGAT2 is that it's highly specific to reduce triglycerides in the liver. And so we think of it as a very specific reagent that should have a high substantial benefit in liver fab without any of the sort of issues that trying some of the other drugs such as increasing LDL and that sort of thing. With ANGPTL3 that's a general dyslipidemia agent in our mind. We know that it lowers LDL, we know that it lowers triglycerides. We know that it lowers ApoB100.

    And so in the study that we're conducting we're asking you the question, does that translate to a significant reduction in triglycerides in the liver? And then we'll look at the composite benefit of that drug grams. It could be a candidate for use as a general agent to reduce triglycerides in people with moderately elevated triglycerides. It could be used to treat patients with a broad range of dyslipidemias and it could be used to treat NASH. So if you think about DGAT2, is a very selective and specific liver triglyceride drug primarily, and ANGPTL3 is more a general dyslipidemia drug with NASH as opportunity among the several that we will pursue. That will be the way I think about it.

    Yale Jen -- Laidlaw & Company -- Analyst

    So would that be -- may be in more specific to say that was targeting to a early disease process of the NASH, but not necessarily into the fibrosis progress into the fibrosis condition?

    Stanley T. Crooke -- Chairman of the Board & Chief Executive Officer

    Well, that's correct. These two drugs are focused on the lipid which is the driver of the disease, and so we believe that as we lower the liver triglycerides, we will affect the progression of the disease and reduce the progression of disease. We have other agents that are coming that are focused on the fibrotic part of the process as well. So what we are going to be doing over the next little bit, is looking at the data that we have in each of these drugs and sliding down for the best patient population for each of the drug. We think this part of -- this component of our pipeline is really quite exciting.

    Yale Jen -- Laidlaw & Company -- Analyst

    Maybe one more question --

    Stanley T. Crooke -- Chairman of the Board & Chief Executive Officer

    And it also demonstrates the power of antigens. We can create selective drugs to target different targets, different parts of pathways, different parts of causes of these complex multi-factor diseases. And then let the data speak and tell us where we should be positioned each one of our opportunities.

    Yale Jen -- Laidlaw & Company -- Analyst

    Yes, maybe one more question regarding the Huntington disease. You say there's two studies and the first study mainly focus on the reduction of the Huntington proteins. And -- but that study you're also monitoring some kind of symptomatic differences over times and maybe have some sort of readout even before the second study is fully enrolled. Is that the plan or does that.

    Stanley T. Crooke -- Chairman of the Board & Chief Executive Officer

    No, that's correct. That's the open label extension and we are encouraged by what we've been seeing. And as Brett said, we do believe that Roche will be providing updates on the progress in that study in 2019 although I can't speak for Roche in more detail.

    Yale Jen -- Laidlaw & Company -- Analyst

    And does the drug have two different -- there is a cohort A and B is at different level of the -- as that tend to be administrated.

    Stanley T. Crooke -- Chairman of the Board & Chief Executive Officer

    I think the open label extension is going simply at the highest dose.

    Damien McDevitt -- Chief Business Officer

    Correct.

    Yale Jen -- Laidlaw & Company -- Analyst

    Okay. Great. Thanks a lot. I appreciate it.

    Stanley T. Crooke -- Chairman of the Board & Chief Executive Officer

    You bet.

    Operator

    And our next question comes from David Lebowitz with Morgan Stanley. Please go ahead with your question.

    David Lebowitz -- Morgan Stanley -- Analyst

    Thank you very much for taking my question. With respect to TEGSEDI reimbursement, could you run us through I guess what types of -- what pieces of information payers in the early run have requested regarding patients and discovering the reimbursement process understanding that you haven't actually finished the whole process yet with patients?

    And then beyond that, what is your expectation for turnaround time from when a patient initially meets with the doctor regarding potentially getting prescribed TEGSEDI to beginning the REMS process and eventually becoming paid and reimbursed it on drug?

    Stanley T. Crooke -- Chairman of the Board & Chief Executive Officer

    I'm going to suggest that you address those questions primarily to Akcea. There are a lot of detail in the process. I can give you my sense of what I understand. I know that our colleagues at Akcea have met with many payors before and after launch. And the focus of payors was sort of where you would expect it to be in the benefit versus the cost. And I understand that those conversations have gone extremely well.

    And the Akcea Connect program is really a very robust highly focused on getting patients into treatment with the easiest process and the shortest time possible, and facilitating the practitioners' entry into the treating of the patient and taking advantage and taking care of the time of the practitioner who manage these patients.

    So, it's short, but I can't tell you the exact time between start and finish. And I suspect that we really won't know for a while just how it's all going to work until we did a lot more experience. And I'm sure as we gain experience, we'll be able to be even shorten it further.

    David Lebowitz -- Morgan Stanley -- Analyst

    Thank you very much for taking my question.

    Stanley T. Crooke -- Chairman of the Board & Chief Executive Officer

    Yes. If that is the last question, so I'd like to bring the call to a close. Once again, thanks everyone for joining us today. I very much appreciate your interest and the questions that you've asked. We encourage you to stay tuned for APO(a)-LRx deal that will be presented in more detail this Saturday at AHA. And we look forward to seeing you at our Investor Day in New York in which we'll have the opportunity to provide a significant -- significantly greater update on essentially everything that we're doing.

    What we are really excited about is that we're progressing to commercializing our two new drugs while SPINRAZA continues to perform well, advancing our pipeline continuing to advance the technology. We're witnessing the improvements in the technology being manifested in the performance of our drugs across the board, and we're doing all that while we're growing operating profits and we're cash accretive. We think that's an exciting story, and we're looking forward to telling it in more detail in our Investor Day. Thanks very much.

    Operator

    The conference has now concluded. Thank you for attending today's presentation. You may now disconnect.

    Duration: 61 minutes

    Call participants:

    Wade Walke -- Vice President, Investor Relations

    Stanley T. Crooke -- Chairman of the Board & Chief Executive Officer

    Elizabeth L. Hougen -- Senior Vice President, Finance & Chief Financial Officer

    Damien McDevitt -- Chief Business Officer

    Brett P. Monia -- Chief Operating Officer and Senior Vice President, Translational Medicine

    Tyler Van Buren -- Piper Jaffray -- Analyst

    Ben Burnett -- Stifel -- Analyst

    Chad Messer -- Needham & Company -- Analyst

    Gena Wang -- Barclays -- Analyst

    Jessica Fye -- JPMorgan -- Analyst

    Yanan Zhu -- Wells Fargo -- Analyst

    Vincent Chen -- Bernstein -- Analyst

    Ritu Baral -- Cowen & Company -- Analyst

    Yale Jen -- Laidlaw & Company -- Analyst

    David Lebowitz -- Morgan Stanley -- Analyst

    More IONS analysis

    Transcript powered by AlphaStreet

    This article is a transcript of this conference call produced for The Motley Fool. While we strive for our Foolish Best, there may be errors, omissions, or inaccuracies in this transcript. As with all our articles, The Motley Fool does not assume any responsibility for your use of this content, and we strongly encourage you to do your own research, including listening to the call yourself and reading the company's SEC filings. Please see our Terms and Conditions for additional details, including our Obligatory Capitalized Disclaimers of Liability.

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    District 181 Welcomes New Staff Members for 2012-13 | killexams.com real questions and Pass4sure dumps

    This post was contributed by a community member.

    New Administrators (alphabetical by last name)

     Christine Cagney (Principal, Walker School) has a B.S. in Business Administration from Fordham University, as well as an M.A. in Teaching in Special Education and an M.Ed. in Administration and Supervision, both from National Louis University. Ms. Cagney was an Assistant Principal at Hunting Ridge Elementary School in Palatine Community Consolidated School District 15 for two years and was a special education teacher in Woodridge School District 68 for four years.

    Deborah Doyle (Pupil Services Administrator) has 16 years of experience in schools. Ms. Doyle worked for eight years in Naperville Community Unit School District 203 as an Assistant Director for Pupil Services and as an Assistant Principal, one year in Birmingham Schools as a Special Education Department Chair, two years in Clarkston Community Schools as a Supervisor of Student Support Services and a middle school special education teacher, one year as a special education teacher in Downers Grove, and four years as a special education teacher in Lockport. She earned a B.S. in Special Education from the University of Wisconsin - Oshkosh and an M.A. from Governors State University.

    Gary Frisch, CPA (Assistant Superintendent for Business) comes to District 181 with 25 years of experience in school business management, including 19 years as the chief school business official. Mr. Frisch most recently worked at Barrington Community Unit School District 220 and in Glenbard Township High School District 87. He serves as an adjunct professor at Aurora University and Concordia University, teaching graduate courses in school finance and school ethics. Mr. Frisch earned his B.S. in Business Administration from Illinois State University – Normal and his M.S. in School Business Management from Northern Illinois University – DeKalb. Mr. Frisch has a Type 75 certificate and Chief School Business Official endorsement.

    Casey Godfrey (Principal, The Lane) had been principal of Fairmount Elementary School in Francis Howell School District in Missouri for the past three years. Prior to that, Mr. Godfrey worked in the Lincoln County R-III School District in Missouri, where he was a teacher and later a principal of Hawk Point Elementary. He began his career in education as a 4th and 5th grade teacher at William Cappel Elementary. He has an M.Ed. from Lindenwood University in Missouri, in addition to a B.S. in Elementary Education from Murray State University in Kentucky.

    Bridget McGuiggan, APR (Director of Communications) served as the Community Relations Coordinator at Orland School District 135 for six years before joining District 181 in July. Prior to working in Orland 135, she was the Coordinator of Marketing and Public Relations at Queen of Peace High School, her alma mater. Her B.S. is in Mass Communications and Marketing, earned from Saint Joseph's College in Indiana. Additionally, she has earned Accreditation in Public Relations (APR) and is Past President of the Illinois Chapter of the National School Public Relations Association.

    Dr. Kurt Schneider (Assistant Superintendent for Learning (Pupil Services)) comes to District 181 from Wisconsin, where he had been the Co-Administrator of Teaching and Learning, Director of Student Services, for the Stoughton Area School District for the past eight years. Dr. Schneider began his career as a high school special education teacher at Madison East High School. He has served as an adjunct university instructor for graduate and undergraduate courses in the Departments of Educational Leadership and Policy Analysis and Rehabilitation Psychology and Special Education at the University of Wisconsin-Madison, and also at Edgewood College in Madison. He earned a doctorate in educational administration, a master's degree in special education and a bachelor's degree in special education, all from the University of Wisconsin - Madison.

    New Teachers, Interventionists, Therapists (Alpha by Last)

     Kristi Awtry (Resource, HMS (.5FTE)) returns to District 181 this year after serving as a long-term substitute. Her experience includes work at Elm, Oak, and HMS, in addition to four years of experience in the Oklahoma area with Pre-K, 1st grade, and 7th and 8th grade students. She has a B.S. in Elementary Education from the University of Central Oklahoma and has completed coursework in the special education field and earned a Learning Behavior Specialist I endorsement.

    Karen Berman (ECE, Sp. Ed., Oak) is no stranger to Early Childhood Education, with experience in Early Childhood programs in both Waukegan and Palos Heights schools. She has a B.S. in Early Childhood Education and an M.Ed. in Early Childhood Special Education, both from the University of Illinois at Urbana-Champaign. Ms. Berman has also earned a Learning Behavior Specialist I endorsement.

    Kathryn Cox (Science / Language Arts, Grade 6, CHMS) holds a B.A. in Elementary Education with a minor in Biology from Elmhurst College, where she graduated with Highest Honors and was a member of the Kappa Delta Pi Honor Society. Ms. Cox has seven years of experience in schools, including one year with Keeneyville Elementary School District 20 in Roselle and six years with District 181 at both CHMS and HMS.

    Jessica Czerniuk (P.E., Madison (.94FTE)) will bring experience in Physical Education from two previous districts when she comes to Madison. Ms. Czerniuk was a P.E. teacher in South Holland School District 151 and Maercker School District 60. She has a B.A. in Kinesiology and Physical Education from Northern Illinois University and an M.A. in Curriculum and Instruction from Olivet Nazarene University.

    Jennifer Duffy (Assistive Technology, District-wide (.5FTE)) will spend time in all District 181 schools through her role in Assistive Technology. She earned a B.A. in Special Education from Northern Illinois University and has completed coursework related to brain-based learning and technology for students with disabilities. Ms. Duffy previously worked for the Kendall County Special Education Cooperative and in Indian Prairie School District 204, serving students in Aurora and Naperville. Ms. Duffy is currently a Literacy Consultant for Gretchen Courtney & Associates, Ltd.

    Erin Eder (School Psychologist, District-wide) holds a B.S. in Psychology from the University of Illinois Urbana-Champaign and an Educational Specialist degree in School Psychology from National-Louis University. Her previous work experience includes three years as a school psychologist with the Southern Will County Cooperative for Special Education.

    Jean Fitzgerald (Art / Computer Graphics / MS Skills, CHMS (.5FTE)) is a winner of the 2011 Hillbrunner Artists Book Fellowship through the School of the Art Institute of Chicago, where she earned an M.A. in teaching. Ms. Fitzgerald also holds a B.F.A. in Painting from the University of Michigan.

    Laura Ghera (Music, Monroe) comes to District 181 with experience as a chorus and general music teacher, with time spent in Butler School District 53, Geneva Community Unit School District 304, and Lisle Community School District 202. She also taught e-Learning for District 53. Mrs. Ghera earned a B.A. in Vocal Performance and Hispanic Studies from Illinois Wesleyan University and an M.M.Ed. from the VanderCook College of Music.

    Karen C. Johnson (Balanced Literacy Coach, District-wide) will work with students at all grade levels through her role as a Balanced Literacy coach. With a B.A. from Northeastern Illinois University, an M.A. in Reading from National Louis University, a Learning Behavior Specialist endorsement, and training in Reading Recovery, Ms. Johnson is ready to succeed in District 181. Her experience includes work in Naperville Community Unit School District 203 and Plainfield Community Consolidated District 202, where she earned an award from the Coordination of Administration and Parents Groups for Educational Efficiency.

    Dr. Kathy Kula (School Psychologist, District-wide) holds a B.S. in Psychology and Sociology from the University of Illinois at Urbana-Champaign and an M.A.T. in Elementary Education from Dominican University, as well as an M.Ed. in School Psychology and a Ph.D. in School Psychology, both from Loyola University Chicago. Dr. Kula's previous work experience includes an internship with Park Ridge-Niles School District 64, a specialty practicum at Edwin G. Foreman High School, and a practicum at Morton West High School. She also taught 6th and 7th grade math, science, and social studies at the Chicago International Charter School in Washington Park.

    Justine Legner (3rd Grade, Prospect) taught math and reading at District 181's The Lane and holds a B.A. in K-9 Elementary Education from North Central College.

    Cherise Madden (Resource, Elm (.5FTE)) earned a B.A. in Elementary Education from Elmhurst College and an M.A. Reading Specialist degree from National Louis University. Ms. Madden also holds a Certificate of Advanced Instruction in Special Education. Her background includes teaching 1st grade in Melrose Park, 2nd and 3rd grade in Elmwood Park, and kindergarten, 1st grade, and 2nd grade for St. Giles School in Oak Park.

    Juliette Nardulli (Resource, Oak) is currently working toward an M.A. Reading Specialist degree from Concordia University. Mrs. Nardulli earned a B.A. in Elementary Education from Benedictine University and holds a Learning Behavior Specialist endorsement from Roosevelt University. Mrs. Nardulli's experience includes teaching 1st grade and kindergarden at Kingswood Academy in Darien. She also taught 4th grade at Noonan Academy in Mokena. Mrs. Nardulli served as an instructional aid at Oak and as a long-term substitute in Monroe and Madison Schools in District 181 in the 2011-12 school year.

    Meg Neubauer (Social Worker, Madison) earned both a Bachelor's and Master's degree in Social Work from Loyola University, where she also earned a B.A. in Sociology. Ms. Neubauer holds a Type 73 certificate, as well. She has been an Early Childhood Social Worker in McHenry School District 15 and in the LaGrange Area Department of Special Education (LADSE).

    Margo Rodenbostel (Social Studies, CHMS (.33FTE)) worked in District 181 for three years before returning now as a 6th grade social studies teacher at CHMS. She has a B.A. in International Relations from the University of Wisconsin – Madison and an M.A. in Education from DePaul University.

    Ele Santini (Social Worker, CHMS) has a B.A. and an M.A. in Social Work from the University of Illinois at Chicago, in addition to a Type 73 certificate. She is a Licensed Clinical Social Worker and Accredited Case Manager, as well. Ms. Santini served as a social worker for 11 years in a medical setting and also interned as a social worker at HMS.

    Chris Taylor (Intermediate (3-5), Monroe) has an M.A. in Teaching with Certification from Aurora University and earned a Learning Behavior Specialist I endorsement. Mr. Taylor worked for two years in Elmhurst Community Unit School District 205 as a 5th grade teacher. He also taught 5th grade in Plainfield Community Consolidated School District 202.

    Lindsay Wagner (4th Grade, Oak) comes to District 181 from the Colorado area, where she taught 4th and 5th grade literacy. She also served as a long-term substitute for 4th grade at Oak in District 181 and also in 1st and 4th grades in Western Springs District 101. Her previous work experience also includes seven years in advertising. Mrs. Wagner earned a B.A. in Journalism and Mass Communications from the University of Iowa and has completed graduate work towards an elementary license and an elementary literacy leadership endorsement at the University of Colorado at Denver.

    Patricia Ward (SLP for ECE, Oak) has an M.S. in Speech-Pathology from Marquette University and is certified in Neurodevelopmental Treatment. She is presently studying for Board Certified Behavior Analyst certification in Applied Behavioral Analysis at the Chicago School of Professional Psychology. Ms. Ward previously worked for LaRabida Children's Hospital, Children's Memorial Hospital, and a private practice in Orland Park, in addition to time in Naperville Community Unit School District 203. As a member of the American Speech-Language-Hearing Association, Ms. Ward was presented with the Award for Continuing Education in recognition of continued professional study.

    Aleisa Woodward (1st Grade, Oak) worked in Georgia's Whitfield County School System and then in Pleasantdale School District 107 in Burr Ridge, both for four years as a kindergarten teacher. Ms. Woodward most recently taught kindergarten and 2nd grade for one year each at The Lane. She has a B.S. in Early Childhood Education from the University of West Georgia.

    Polly Yukevich (Orchestra, District-wide) can tell her new District 181 students about an exciting project she completed with a previous district, in which she implemented a $7,000 ukulele grant and worked with world-renowned ukulele player Jake Shimabukuro. Ms. Yukevich also led her students in a performance at the 2012 Illinois Music Educators Conference. Her previous districts include Glenview Public School District 34 and Community Unit School District 300. Ms. Yukevich holds a B.M.Ed. from the VanderCook College of Music and an M.M.Ed. from the University of Illinois at Urbana-Champaign.

    Previously Employed (Moving to Full-Time OR New Positions)

    The following individuals were previously employed in District 181 and have moved positions for the 2012-2013 school year and/or moved from part-time to full-time: Doug Eccarius, Jamie Guerin, Ehren Hill, Meghan Kappmeyer, Justine Legner, Eileen Logan, Joan Rickert, and Kevin Russell.

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