|Exam Name||:||Advanced Collaboration Architecture(R) Sales Specialist|
|Questions and Answers||:||50 Q & A|
|Updated On||:||February 15, 2019|
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700-037 exam Dumps Source : Advanced Collaboration Architecture(R) Sales Specialist
Test Code : 700-037
Test Name : Advanced Collaboration Architecture(R) Sales Specialist
Vendor Name : Cisco
Q&A : 50 Real Questions
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ROSEMONT, ill., March 06, 2018 (GLOBE NEWSWIRE) -- LaSalle options, a leading company of know-how lifecycle administration functions, announced these days that it has renewed its Cisco advanced Collaboration structure Specialization. The specialization recognizes that LaSalle has again fulfilled the practicing necessities and application prerequisites to sell, design and deploy comprehensive Cisco Collaboration solutions.
As a Cisco superior Collaboration Specialization companion, LaSalle options has proven its ability to give subtle, price-brought Cisco options via in-depth income capabilities, technology talents and repair offerings. Cisco superior Specialization companions work with new and latest applied sciences to align accessories of those architectures with their consumers’ strategic desires, helping transform enterprise processes, raise organizational effectivity and accelerate the time to market.
“we're proud to once again obtain advanced Collaboration architecture Specialization from Cisco,” talked about Steven Robb, president of the solutions group at LaSalle solutions. “Our purchasers seem to us for support enhancing collaboration throughout their organizations. This specialization is as a result of the hard work LaSalle solutions places in each year to make sure that we now have the greatest applied sciences and capabilities to bring up consumer collaboration innovations to greater sustainable, unified options.”
About LaSalle options
based in 1980, LaSalle options is a leading issuer of know-how lifecycle asset administration functions. LaSalle allows its consumers to enrich their expertise operations via greater processes, administration and reporting for better planning and return on funding. LaSalle solutions’ approaches, excellent consumer service and strong, market-main cloud-based toolset, LAMP, enable valued clientele to achieve better enterprise effects through transparency and respectable effects at their fingertips.
LaSalle solutions is a division of MB equipment Finance LLC, a subsidiary of MB fiscal bank, N.A., a commercial financial institution headquartered in Chicago. MB fiscal Inc. is the publicly traded conserving company for MB fiscal financial institution, N.A. and is traded on the NASDAQ as “MBFI.”
For greater guidance on LaSalle options, please visit www.elasalle.com and www.YouTube.com/LaSalleSolutions.
LaSalle options and LAMP are registered emblems of LaSalle solutions in the united states.Press Contact Beth Kirshenberg LaSalle options 847.823.9600
Rosemont, Illinois, u.s.Press Contact Beth Kirshenberg LaSalle options 847.823.9600
includes Cisco Hosted Collaboration solution (HCS) for the Contact center, becoming the primary companion to offer this service over its amenities across the Caribbean and Latin American vicinity
MIAMI, FL, March 21, 2016 – C&W company, a division of Cable & wireless Communications Plc (CWC), these days announces that it will offer Cisco® Unified Communications as a provider over its multiprotocol label switching (MPLS) community to its consumers across the Caribbean and Latin American region.
The C&W company portfolio will also include the Cisco Hosted Collaboration solution (HCS) for the Contact middle. C&W company will develop into the primary service provider in the Caribbean and Latin the usa to present a contact center in the cloud, which represents a more agile, productive, flexible and scalable contact core solution.
Cisco HCS is a next-generation unified communications and collaboration platform for companions who want to offer interesting Cisco collaboration technologies using hosted and managed models. by drinking collaboration capabilities from the cloud, businesses have the flexibility to choose the collaboration purposes selected to their requirements.
Cisco HCS should be hosted on the C&W enterprise facts facilities and may be delivered to purchasers over C&W Communications’ world-classification, SIP-enabled fiber IP (terrestrial and submarine) fault-tolerant networks, overlaying over forty eight,000 kilometers of fiber across the Caribbean and Latin American place, permitting C&W company to carry totally at ease and official data, voice and video services effectively to its valued clientele.
C&W business will present valued clientele:
additionally, existing Cisco collaboration consumers can migrate their “on premises” answer into this cloud and hold their funding in licensing.
C&W business is a Cisco Gold certified partner with specializations in superior Collaboration structure, superior records core architecture and Cisco Managed carrier provider, amongst others.
“In today’s altering world, assorted corporations are demanding new and extra effective easy methods to collaborate, enhance person productiveness and raise consumer experiences. by way of partnering with Cisco, we are extra empowering our valued clientele by using supplying and managing a cloud features answer to meet their wants. we are completely satisfied to have Cisco’s endorsement and excited to be implementing the primary Cisco HCS for Contact center within the Caribbean and Latin the us and produce CCaaS and UCaaS across the area.”
“Cisco HCS gives you the merits of Cisco’s collaboration solutions, with the economic, operational, and strategic advantages linked to cloud capabilities. Now, C&W enterprise could be in a position to offer collaboration equipment to their shoppers within the location in a subscriber-based carrier this is cost effective and in a extremely comfortable ambiance.”
About Cable & instant Communications Plc
Cable & instant Communications Plc (CWC) is a full carrier communications and leisure provider, working in Latin the united states and the Caribbean. With annual income of over US$2.four billion, it operates each cellular and stuck networks, supported by way of submarine and terrestrial optical fiber backhaul capability. CWC gives you advanced high-velocity mobile information, broadband and video features. It has leading market positions in cell, fixed Line, Broadband and Video purchaser offers. via its business division, CWC gives data center internet hosting, home and foreign managed community features, and customised IT provider solutions, employing cloud know-how to serve business and executive shoppers.
The neighborhood also operates a state-of-the-artwork subsea fibre optic cable community that spans more than 48,000 km – probably the most extensive in the area – as well as 38,000 km of terrestrial fibre offering wholesale and provider backhaul capacity.
CWC has greater than 7,300 employees serving 6.4 million purchasers (cell four.1m; fastened Line 1.1m; Video 470k and Broadband 690k) across 42 countries. The community’s leading manufacturers include; LIME and circulation within the Caribbean; BTC in the Bahamas; Mas a Mobil company in Panama; C&W company and C&W Networks. CWC is the market chief in most items provided and territories served. it is an enormous contributor to local communities via its company social accountability programmes.
Cable & instant Communications Plc’s shares are quoted on the London stock trade beneath the ticker CWC. The group is headquartered in London with its operational hub discovered in Miami, inside close proximity to the Caribbean and Latin the us.
For greater tips consult with: www.cwc.com.
Cisco (NASDAQ: CSCO) is the worldwide chief in IT that helps agencies seize the opportunities of tomorrow by way of proving that superb things can ensue for those who join the previously unconnected. For ongoing information, please go to http://thenetwork.cisco.com
# # #
Cisco and the Cisco emblem are emblems or registered emblems of Cisco and/or its affiliates within the U.S. and different international locations. a catalogue of Cisco's trademarks can also be discovered at www.cisco.com/go/logos. Third-birthday celebration emblems mentioned are the property of their respective homeowners. the use of the observe associate does not indicate a partnership relationship between Cisco and any other enterprise.
Chicago, IL, united states – might also 10, 2012 – To assist the expanding role of collaboration options that leverage the intelligence of the community, LaSalle options announced today that it has done the advanced Collaboration structure Specialization from Cisco. This specialization acknowledges LaSalle options as having fulfilled the training necessities to sell, design and installation comprehensive Cisco® Collaboration architecture options.
As a Cisco superior Collaboration architecture really good accomplice, LaSalle options has invested in the practicing required to carry differentiated company value in the course of the integrated, open groundwork of the collaboration structure. Cisco superior Collaboration structure really expert partners work with new and current applied sciences to align components of this structure with their purchasers’ strategic desires, assisting radically change company methods, enhance organizational efficiency and accelerate the time to market.
“we're proud to achieve the Cisco advanced Collaboration architecture Specialization,” says Steven Robb, vp and frequent supervisor of LaSalle solutions. “This certification is a pleasant complement to our Cisco superior Unified Collaboration Specialization. with the aid of providing a full latitude of Cisco solutions – from collaboration to records middle - we allow our shoppers to fulfill today’s company challenges and construct their competitive area.”
“The Cisco advanced Collaboration structure Specialization is designed to assist Cisco channel companions meet a wide array of consumer needs,” talked about Richard McLeod, senior director of collaboration architecture for the worldwide associate group at Cisco. “reaching the Cisco superior Collaboration architecture Specialization gives LaSalle solutions with entry to finished revenue and technical practicing in addition to help from Cisco.”
The Cisco Resale Channel application offers partners with the practicing required to build sales, design and technical skill after which validates their knowledge through a 3rd-birthday celebration audit.
About LaSalle solutions:
LaSalle options is a leading company of life-cycle management functions of expertise and capital property from acquisition and financing via IT asset administration, renovation and disposition. LaSalle’s approaches, astounding client service, and robust online toolset LAMPSM, enable to greater economically and comfortably manipulate time, maintenance credits and equipment deployment, tracking and decommissioning.
centered in 1980, LaSalle solutions is an independently operated company and a subsidiary of MB monetary, a publicly traded Chicago-based mostly financial institution holding company. MB fiscal is traded on the NASDAQ as "MBFI.”
gain knowledge of greater via travelling www.elasalle.com or www.YouTube.com/LaSalleSolutions.
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We’ve already heard that VW and Ford have agreed to “investigate collaboration on....electric vehicles,” but now a new report by German newspaper Der Tagesspiegel suggests that VW’s ideas on EV collaboration span well beyond Ford. According to the story, VW wants its MEB platform to become an industry standard.
Volkswagen has economies of scale down to an art. The company sells a ridiculous number of cars across a bunch of brands, and it’s proven with its MQB platform that it can build many different kinds of vehicles of various shapes and sizes on a single vehicle architecture.
VW plans to replicate its MQB strategy with MEB, which stands for Modular Electric Drive Matrix, and promises to build 10 to 15 million small cars, luxury sedans, SUVS, and vans on those bones. But that may just be the beginning, with Taggesspiegel speaking with the VW brand’s chief strategist Michael Jost about VW’s hopes to put the MEB platform in the lineups of more than just VW group brands. From the story (translated from German):
The VW Group wants to establish its production platform for electric cars as an industry standard and open for competitors. “Our modular system for electric cars - the modular electrification kit (MEB) - should be a standard not only for the VW Group,” said Michael Jost, head of strategy of the core brand VW, the Tagesspiegel. The Volkswagen Group wanted to open the MEB and offer it to the entire industry.
The story goes on to write that Volkswagen is “advanced discussions” with other automakers, “especially in the volume segment,” writing:
“This is a paradigm shift for us,” Jost told the Tagesspiegel. “We have no elite plan, but a plan for the company.” The car manufacturer is a cost and scalability “champion in the industry.” According to reports, the US company Ford is considering licensing the electrical construction kit.
The idea of dozens of cars from various automakers all driving around on VW’s MEB platform may sound wild, but it actually may not be a bad idea for an automaker who doesn’t want to spend billions on its own electric vehicle platform which will, very possibly, have a heck of a lot in common with VW’s MEB. Plus, this strategy could have huge benefits for consumers in terms of overall pricing and easy of vehicle modification and repair.
No, this doesn’t mean all the cars will look or perform the same, just that the basic safety structure and suspension hard points, as well as powertrain and drivetrain layouts, would be more or less common. Changes to the battery size, motor output, overall dimensions (wheelbase, track width, cowl length), and sheetmetal could yield all sorts of different vehicle designs.
My coworker Jason Torchinsky has been preaching this idea for a while, culminating in his masterpiece “The Best Thing That Can Happen To Electric Cars Is What Happened To PCs In The 1990s,” in which he writes:
But EV technology is significantly different than conventional car technology, and those differences open up production and sales options that haven’t previously been available.
First, the fundamental drivetrain technology of EVs is far simpler than internal-combustion cars, and it’s already being realized that electric drivetrains are becoming something of a commodity, and not the huge differentiator that drivetrains are in ICE cars.
EVs are, to a far greater degree than a conventional car, plug-and-play. They have the potential to be far more modular than cars are now, and that opens up many new options.
If, somehow, the EV makers can agree to a comprehensive set of standards for battery types, motors, drivetrains, a universal interface for instrument clusters, center stack infotainments systems, autonomous driving systems, and so on, the industry could be as flexible and powerful as the computer industry.
I’ve reached out to VW to learn more. I’m specifically interested in learning what “open for competitors” means. Would VW build the platform and license it out to others? And who are these companies with whom VW is allegedly in “advanced discussions”?
This is an exciting idea—one that makes sense in many ways—but we’ll have to see who latches on.
Today, the market is brimmed with new technologies. Companies are integrating the latest technologies into their existing goals with proper planning. Some of the most promising technologies of today’s ever-changing market are Virtual Reality, Augmented Reality, blockchain, and IoT (Internet of Things).
These technologies offer various types of opportunities to businesses and enable them to use data in this constantly evolving market and create new, innovative ways to interact with the users.
With each passing day, virtual reality is expanding among consumers. Mobile app developers are focusing on developing virtual reality devices that have the potential to turn mobile devices into virtual reality gadgets. Whether it is a consumer or an enterprise, the demand for VR apps is picking pace in every sector.
Virtual Reality is transforming the way people live their life, do business, and communicate with others. Those who adopted this technology are expanding their business and those who lack such expertise will lose the benefits VR provides.
Before diving into what VR is capable of and how it is benefiting industries to expand, let’s determine what is virtual reality.
In VR, wearable devices such as headsets, bands, and earphones deliver technology. All this engagement is implemented through a screen placed in front of users’ eyes, controlled by the mobile phone, computer, and gaming console. Specialized software, 3D audio, and sensors make the virtual experience a real one. VR devices enable users to interact with the virtual world instinctively.Sectors That Are Leveraging VR Potential Automotive Industry
Virtual Reality has completely changed the process of design, purchasing, and safety in the automotive industry. The realistic elements present in VR technology enable developers and designers to check and analyze how new vehicles will look as well as perform without any need to build multiple models.
In spite of that, the outside environment can be virtually replicated in order to conduct safety trials on the vehicles without putting extra time and energy to run the tests. Today, many big brands such as Volvo, Ford, and Hyundai are leveraging VR for design and sales purpose. Companies have made these vehicles accessible to the customers to try everything from test driving to examining vehicle features. With VR, the need for a physical dealership showroom is vanishing slowly.Retail Sector
The retail sector has experienced huge growth with the intervention of virtual reality. With VR, retail showrooms can showcase everything from their store without physically keeping the product on-site. Whether it is showing furniture model or different fabric shade, retailers are able to show it to the customers and get their feedback about various products and insights on what works best for them.Healthcare Sector
Realistic virtual environment and virtual human anatomy model help healthcare providers get a clear picture of the human body’s functioning without working on a real one. This can be proven beneficial for everyone from experienced health specialists to the newcomers who perform high-risk procedures. Hence, Virtual Reality training provides such professionals with hands-on training to enable them to treat patients in a more advanced way. It will not only reduces the chance of malpractice and negligence but also lowers liability insurance cost.Architecture
Virtual reality has benefitted architecture sector on a large scale. VR has the potential to bring transformation in the way engineers work on designs, as it gives them several options to experiment with different aspects of a building like material, lighting, and layout. VR also enables customers to go for a virtual tour of such buildings to get the look and feel. In addition to this, when it comes to editing the architectural design, doing it before or during the construction will save a significant amount of money, avoid miscommunication, and prevent complicated re-works.Skilled Trades
What modeling is for automotive virtual reality training, gamification is for construction and skilled trades. Rather than using hardware, VR lets workers practice different tools in a virtual environment. VR training saves a significant amount of money, as there would be no more spending on materials. Today, there are many similar low-risk as well as high-risk activities possible with VR, such as forklift operations, welding, and paintings, where labors have the benefit of refining their skills before diving into the physical work.Tourism Industry
With VR technology, getting guided tours across the world is an easy task. It allows people to virtually visit the places before planning an actual trip. This helps travelers learn more about less-explored and smaller places. Apart from that, many traveling firms and hotels prefer showcasing their venue and accommodation to the tourists by using interactive technologies like VR to let them explore and experience their services and book.Aerospace Sector
The aerospace sector is one of the highly immersive areas where VR technology has created an impact. VR enables collaboration in building and maintenance process. It supports better communication as well as improves understanding among employees working in different departments. Whether it is an engineer, manufacturer, or designer, everyone is able to interact better as well as create quality products with improved visualization.
VR technology allows realistic visualization and helps departments establish a strong relationship with each other to have a better understanding at every designing and building stage. With a proper communication medium, service workers, engineers, pilots, and ground controllers can maintain the final product efficiently.Education Sector
From mechanics to surgeons, everyone is harnessing the benefits of VR technology. The education industry is leveraging VR for training purposes. For younger students, it includes virtual field trips, immersive games, and interactive session for those who need special education. Such interactive experiences combined with gaming sessions increase students’ interests and make them highly innovative. They are able to do certain tasks virtually that can’t be achieved in reality. It serves as a new approach that inspires innovative learning experience among students.Wrapping Up
Virtual Reality is considered to be in its early stages even though it has achieved a lot in almost every sector. Whether it is healthcare or automotive, everyone is leveraging VR technology to improving user experience as well as reaching to more users. If you are considering to develop an app with VR technology, then it is the best time to catch up.
iot ,vr ,virtual reality ,mobile ,app development ,automotive ,healthcare ,education
Allschwil, Switzerland - February 7, 2019Idorsia Ltd (SIX: IDIA) today announced its financial results for the full year 2018.
Jean-Paul Clozel, MD and Chief Executive Officer, commented: "Idorsia made outstanding progress with all of our strategic priorities in 2018. We advanced our late-stage pipeline, bringing four products into Phase 3 development. On top of that enormous undertaking, we have advanced our early-stage development pipeline and continued our discovery efforts. With the appointment of Simon Jose as Chief Commercial Officer, we have started to build a global commercial organization to realize the full potential of Idorsia's innovative pipeline and make strategic decisions on how to commercialize our broad range of assets."
Financial resultsUS GAAP results Full Year Fourth Quarter in CHF million, except EPS (CHF) and number of shares (million) 2018 2017 2018 2017 Revenues 61 158 41 158 Operating expenses (432) (166) (141) (87) Operating income (loss) (371) (8) (101) 71 Net income (loss) (386) (14) (108) 68 Basic EPS (3.10) (0.13) (0.83) 0.57 Basic weighted average number of shares 124.8 114.0 131.1 119.1 Diluted EPS (3.10) (0.13) (0.83) 0.43 Diluted weighted average number of shares 124.8 114.0 131.1 157.9
For the Full Year 2018, US GAAP net loss amounted to CHF 386 million compared to CHF 14 million for the period ending December 31, 2017. The increase of the net loss was mainly driven by lower revenues and higher operating costs.
Revenue of CHF 61 million in 2018 related to deferred contract revenue (CHF 26 million) and an option and sublicensing agreement with Santhera (vamorolone, CHF 34 million) whilst revenue in 2017 of CHF 158 million related to the recognized portion of the upfront milestone received from Janssen (aprocitentan).
Operating expenses of CHF 432 million in 2018 represented 12 months of operations (of which CHF 370 million R&D and CHF 61 million G&A expenses) whilst operating expenses of CHF 166 million in 2017 represented 6.5 months of operations since demerger from Actelion on June 15, 2017 (of which CHF 135 million R&D and CHF 31 million G&A expenses).
The US GAAP net loss resulted in a net loss per share of CHF 3.10 (basic and diluted) for the Full Year 2018 compared to a net loss per share of CHF 0.13 (basic and diluted) for the period ending December 31, 2017.Non-GAAP* measures Full Year Fourth Quarter in CHF million, except EPS (CHF) and number of shares (million) 2018 2017 2018 2017 Revenues 61 158 41 158 Operating expenses (399) (150) (133) (79) Operating income (loss) (339) 8 (92) 79 Net income (loss) (340) 5 (91) 77 Basic EPS (2.72) 0.04 (0.70) 0.65 Basic weighted average number of shares 124.8 114.0 131.1 119.1 Diluted EPS (2.72) 0.03 (0.70) 0.49 Diluted weighted average number of shares 124.8 139.5 131.1 157.9
* Idorsia measures, reports and issues guidance on non-GAAP operating performance. Idorsia believes that these non-GAAP financial measurements more accurately reflect the underlying business performance and therefore provide useful supplementary information to investors. These non-GAAP measures are reported in addition to, not as a substitute for, US GAAP financial performance.
For the Full Year 2018, non-GAAP net loss amounted to CHF 340 million: the difference versus US GAAP net loss was mainly due to depreciation and amortization (CHF 20 million), share-based compensation (CHF 13 million) and non-cash financial expenses (CHF 16 million).
Non-GAAP revenue of CHF 61 million comprised CHF 20 million cash received from Santhera and CHF 41 million non-cash consideration (CHF 15 million with 1 million shares of Santhera and CHF 26 million of deferred recognition from upfront payments in connection with the Roche and Janssen collaboration agreements).
Non-GAAP net loss per share amounted to CHF 2.72 (basic and diluted) for the Full Year 2018 compared to a net profit per share of CHF 0.04 (basic) and CHF 0.03 (diluted) for the period ending December 31, 2017.
André C. Muller, Chief Financial Officer, commented: "In 2018, we completed demerger activities, with all core systems now running independently of Actelion - this is an outstanding achievement in such a short space of time. We also strengthened our cash position so that we can continue to invest in our diverse pipeline of unique assets that offer significant potential to patients and investors alike. Based on the current status and expected progress of the pipeline, excluding unforeseen events and potential milestones payments, Idorsia expects non-GAAP operating expenses for 2019 to be around CHF 530 million."
Liquidity and indebtednessAt the end of 2018, Idorsia's liquidity (including cash, cash equivalents, short- and long-term deposits) amounted to CHF 1,220 million.(in CHF millions) Dec 31, 2018 Sep 30, 2018 Dec 31, 2017 Liquidity Cash and cash equivalents 799 671 622 Short-term deposits 123 132 218 Long-term deposits 298 548 250 Total liquidity* 1,220 1,351 1,091 Indebtedness Convertible loan 372 370 365 Convertible bond 198 198 - Other financial debt - - - Total indebtedness 571 569 365
*rounding differences may occur
Clinical Development PipelineIdorsia has a diversified and balanced clinical development pipeline covering multiple therapeutic areas, including CNS, cardiovascular and immunological disorders, as well as orphan diseases.
The late-stage pipeline advanced significantly in 2018, with four compounds moving into Phase 3 clinical development. All late-stage trials are now recruiting patients, with data expected to be reported in 2020 and 2021.
Details of the Phase 3 programs can be found in a series of investor webcasts published on our corporate website.
Progress was also made with our early-stage compounds by accumulating information on clinical pharmacology in healthy volunteers or conducting Phase 2 profiling in patients.Compound Mechanism of Action Target Indication Status Aprocitentan* Dual endothelin receptor antagonist Resistant hypertension management Phase 3 Clazosentan** Endothelin receptor antagonist Vasospasm associated with aneurysmal subarachnoid hemorrhage Phase 3 Lucerastat Glucosylceramide synthase inhibitor Fabry disease Phase 3 ACT-541468 Dual orexin receptor antagonist Insomnia Phase 3 Cenerimod S1P1 receptor modulator Systemic lupus erythematosus Phase 2 Selatogrel P2Y12 receptor antagonist Acute coronary syndrome Phase 2 ACT-774312 CRTH2 receptor antagonist Nasal polyposis Phase 2 ACT-519276 GBA2/GCS inhibitor Orphan CNS diseases Phase 1 ACT-539313 Selective orexin 1 receptor antagonist Anxiety Phase 1 ACT-709478 T-type calcium channel blocker Epilepsy Phase 1
* In collaboration with Janssen Biotech Inc. to jointly develop and solely commercialize aprocitentan worldwide** Market registration trials are being conducted in Japan
Idorsia has the option to license vamorolone from ReveraGen Inc. and has granted to Santhera Holding Ltd. the option to sub-license vamorolone worldwide for all indications.
Human ResourcesIdorsia created 93 new positions worldwide in 2018, bringing the total number of employees (permanent, post-doc, and apprentices) to 753 (2017: 660).
Annual ReportFull details on the progress made in 2018 are available in Idorsia's 2018 Annual Report, at www.idorsia.com/annual-report
Note to ShareholdersThe Annual General Meeting (AGM) of Shareholders to approve the Annual Report of the year ending December 31, 2018 will be held on Friday May 3, 2019.
Registered shareholders with voting rights individually or jointly representing at least 5% of the share capital of the company, being entitled to add items to the agenda of the general meeting of shareholders, are invited to send in proposals, if any, to Idorsia Ltd, attention Corporate Secretary, Hegenheimermattweg 91, CH-4123 Allschwil, to arrive no later than March 14, 2019. Any proposal received after the deadline will be disregarded.
In order to attend and vote at the Annual General Meeting, shareholders must be registered in the company's shareholder register by April 24, 2019 at the latest.
Results Day CenterInvestor community: To make your job easier, we provide all relevant documentation via the Results Day Center on our corporate website: www.idorsia.com/results-day-center.
Upcoming Financial Updates
Notes to the editor
Letter to Shareholders (as published in Idorsia's 2018 Annual Report on February 7, 2019)
Advancing with speed and agility
In 2018, Idorsia saw advances on all fronts:
Late-stage assets leap forwardOur late-stage pipeline advanced significantly in 2018, with four compounds moving into Phase 3 clinical development. All our late-stage trials are now initiated, with data expected to be reported in 2020 and 2021.
Lucerastat is an oral therapy offering a new treatment approach for patients with Fabry disease. Recruitment for the MODIFY trial started in May and the study is expected to report results in the first half of 2020.
ACT-541468 is a dual orexin receptor antagonist for the treatment of insomnia. It has the potential to deliver fast onset of sleep and a duration of action not exceeding a normal night, while preserving natural sleep architecture. Recruitment for the Phase 3 program started in June and we are on track to report results in the first half of 2020.
Aprocitentan - an orally active dual endothelin receptor antagonist - is being investigated in the PRECISION trial for patients whose hypertension is uncontrolled despite the use of at least three antihypertensive drugs. Patients were enrolled at the first site in June, and we are close to having all sites recruiting as patient screening progresses.
Clazosentan - a selective endothelin (ETA) receptor antagonist - is being developed for the prevention of clinical deterioration due to vasospasm-related delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage. The global REACT study commenced enrollment at the beginning of February 2019.
Development of clazosentan is further advanced in Japan, where a Phase 3 program was initiated by Actelion in 2016; recruitment continues, and the studies are expected to be completed in the first half of 2020. To pave the way for bringing clazosentan to market, we have established Idorsia Japan. This has the additional advantage of allowing us to tailor our other development programs to include Japan at a very early stage.
Building the pipeline of the futureWe are also making great progress with our early-stage compounds by accumulating information on clinical pharmacology in healthy volunteers or conducting Phase 2 profiling in patients.
Two Phase 2 studies with selatogrel, Idorsia's P2Y12 receptor antagonist, met their pharmacodynamic objectives of significantly inhibiting platelet aggregation and showed the desired profile for future development. We are preparing for the end of Phase 2 meetings with Health Authorities where we will discuss the Phase 3 study.
Another example is cenerimod, our selective S1P1 receptor modulator, which is being investigated for the treatment of adults with systemic lupus erythematosus in a multiple-dose, efficacy and safety study. This is the first time S1P1 receptor modulation has been studied in a large clinical trial for patients with lupus, potentially transforming the treatment landscape for this underserved patient population.
And there's much more to come, as Drug Discovery continues to generate the pipeline of the future.
Operational independenceOn the first day after the demerger, Idorsia was operationally fully functional, meaning that our business, research and clinical development could continue without any interruption. However, though Idorsia was launched with a broad pipeline, an established team and with the necessary laboratories and workspaces, we were still reliant on certain services and systems provided by Actelion.
Over the course of 2018, we cut the umbilical cord and we are now fully independent: all of our core systems - from e-mail and data servers to support environments for research and clinical development - have been decoupled from the old infrastructure, and new, highly scalable state-of-the-art solutions have been implemented in all areas of the business.
Completing the value chainIn December 2018, Simon Jose joined the Idorsia Executive Committee as Chief Commercial Officer. He is now creating Idorsia's commercial infrastructure and executing on our strategic priority of being able to take our own research and innovation from the lab to patients. The establishment of a fully functional subsidiary in Japan constitutes a major first step in setting up a global commercial infrastructure.
Building a company with its own commercial infrastructure means that we are in control of the planning, development and implementation of commercial strategies for our assets. This in turn will give us financial independence and sustainability, thus maximizing the potential benefits for Idorsia.
Financing pipeline developmentRather than focusing all our efforts on a single drug, we have advanced all our late-stage assets into Phase 3 simultaneously. We believe that this approach gives us the best chance of achieving success, building the business, and funding future innovations. However, the level of financing required for a diversified drug pipeline can pose certain challenges for a young company. The CHF 505 million raised in July 2018 should give us the necessary leeway to assess the clinical data for our late-stage pipeline and then make the appropriate strategic decisions regarding commercialization.
Committed to creating long-term valueBuilding a company requires an investment of time, effort and money, as well as the confidence of shareholders. We will continue to make these investments to ensure that our innovative medicines can fulfill their potential for the benefit of patients around the world.
Jean-Paul Clozel, Chief Executive Officer Jean-Pierre Garnier, Chairman of the Board
Issuance of new registered sharesIn July 2018, Idorsia placed 11,912,000 new registered shares of CHF 0.05 par value each at CHF 25.62 per new share (the "Offer Shares") with gross proceeds of CHF 305 million. The Offer Shares, corresponding to approximately 10% of Idorsia's currently issued share capital, were issued from Idorsia's existing authorized share capital and ranked pari passu with the existing shares. The listing and the admission to trading of the Offer Shares according to the International Reporting Standard of the SIX Swiss Exchange was effective on July 13, 2018.
Issuance of senior unsecured convertible bondsIn July 2018, Idorsia placed CHF 200 million of senior unsecured convertible bonds (the "Bonds"), due 2024. The Bonds have a maturity of 6 years and are convertible into 5.9 million registered shares of Idorsia, sourced from existing listed conditional share capital, on or after August 27, 2018. The Bonds have a coupon of 0.75%, subject to Swiss withholding tax, and a conversion price of CHF 33.95, corresponding to a conversion premium of 32.5% above the book-building price of the Offer Shares. Holders of the Bonds who convert their Bonds will receive Idorsia shares with a par value of CHF 0.05 per Idorsia share. Idorsia will be entitled to redeem the Bonds at their principal amount (plus accrued interest) in accordance with the terms and conditions of the Bonds at any time (i) on or after August 7, 2022, if the price of an Idorsia share is equal to or exceeds 150% of the then prevailing conversion price over a certain period or (ii) if less than 15% of the aggregate principal amount of the Bonds remains outstanding. The Bonds, unless previously converted or repurchased and cancelled, will be redeemed at 100% of their principal amount.
About IdorsiaIdorsia Ltd is reaching out for more - We have more ideas, we see more opportunities and we want to help more patients. In order to achieve this, we will develop Idorsia into one of Europe's leading biopharmaceutical companies, with a strong scientific core.
Headquartered in Switzerland - a biotech-hub of Europe - Idorsia is specialized in the discovery and development of small molecules, to transform the horizon of therapeutic options. Idorsia has a broad portfolio of innovative drugs in the pipeline, an experienced team, a fully-functional research center, and a strong balance sheet - the ideal constellation to bringing R&D efforts to business success.
Idorsia was listed on the SIX Swiss Exchange (ticker symbol: IDIA) in June 2017 and has over 750 highly qualified specialists dedicated to realizing our ambitious targets.
For further information, please contactAndrew C. WeissSenior Vice President, Head of Investor Relations & Corporate CommunicationsIdorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, CH-4123 Allschwil+41 (0) 58 844 10 10www.idorsia.com
The above information contains certain "forward-looking statements", relating to the company's business, which can be identified by the use of forward-looking terminology such as "estimates", "believes", "expects", "may", "are expected to", "will", "will continue", "should", "would be", "seeks", "pending" or "anticipates" or similar expressions, or by discussions of strategy, plans or intentions. Such statements include descriptions of the company's investment and research and development programs and anticipated expenditures in connection therewith, descriptions of new products expected to be introduced by the company and anticipated customer demand for such products and products in the company's existing portfolio. Such statements reflect the current views of the company with respect to future events and are subject to certain risks, uncertainties and assumptions. Many factors could cause the actual results, performance or achievements of the company to be materially different from any future results, performances or achievements that may be expressed or implied by such forward-looking statements. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those described herein as anticipated, believed, estimated or expected.
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