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644-344 - SP Video Phase III Wireline - Dump Information

Vendor : Cisco
Exam Code : 644-344
Exam Name : SP Video Phase III Wireline
Questions and Answers : 20 Q & A
Updated On : April 17, 2019
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644-344 Questions and Answers

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644-344 SP Video Phase III Wireline

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644-344 exam Dumps Source : SP Video Phase III Wireline

Test Code : 644-344
Test Name : SP Video Phase III Wireline
Vendor Name : Cisco
Q&A : 20 Real Questions

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Cisco SP Video Phase III

Evolution of Key Cisco leadership Positions | killexams.com Real Questions and Pass4sure dumps

Cisco’s lengthy-standing perception has all the time been that groups should evolve to pressure forward and lead through market transitions.  The equal is correct for our government skill.  Evolving our talent requires putting them in new roles, increasing their perspective and ability sets and bringing fresh ideas and energy to the company. here's what we’ve these days performed with Edzard Overbeek’s new flow from SVP of our Asia-Pacific-Japan region to move of our international capabilities company and Bruce Klein’s circulate from SVP of Public Sector sales to the pinnacle of our international associate organization.

during the last yr, we have refocused our engineering organization for agility, more advantageous determination making, and a renewed focal point on innovation.  The market share numbers speak for themselves and our consumer self belief has by no means been enhanced.  we've a powerful leadership group and the enterprise community leaders have tested powerful execution.  Now the time is correct for us to drive the next section of our organizational evolution.

With that, we're blissful to announce Padmasree Warrior will extend her function to develop into Cisco’s Chief technology and approach Officer where she should be chargeable for settling on consumer and business transitions and selecting Cisco’s approach to address them.  Padma will work intently with Cisco’s engineering, container, operations and services management, and may outline strategy, investments, acquisitions and the evolution of Cisco’s know-how companion ecosystem.   additionally, Padma may be liable for idea leadership around Cisco’s products and architectures, technical ability building and recruiting, and she or he will raise her time with external stakeholders.  The business group CTO’s will document dotted line to Padma to allow powerful alignment between technology approach, enterprise method and M&A pastime.  during the last 4 years, Padma has based a major tune record of results, corresponding to constructing Cisco’s method and execution round architectures, cloud, normal expertise approach framework, and attracting and developing business main technical talent.  We look forward to accelerating our market position beneath Padma’s strategic course.

After 13 years of outstanding provider to Cisco, Ned Hooper should be leaving the instant Cisco family to form an impartial funding partnership business and to pursue his intention to be a primary investor.  Ned has been engaged on his plan with us over a few months, and we seem forward to partnering with him in his new activity.  Ned has a distinct passion and ability for funding and approach, and may center of attention on this in the subsequent part of his profession.   Ned pioneered the mannequin for gigantic-scale M&A at Cisco and drove giant transactions for the enterprise corresponding to Tandberg, WebEx, Airespace, Starent and NDS.  additionally, he has managed our $2B funding portfolio with each strategic and economic returns to the business. Ned’s strategy and company building group will now document to Padma.  we would want to thank Ned for his contributions, leadership, friendship and his persistent force to at all times do the right issue for Cisco.

ultimately, Pankaj Patel will assume the management of Cisco’s engineering organization.  Pankaj will force innovation, operational excellence and agile construction throughout our products, options and architectures, and continue to enhance our relevance with our expanding customer base.  Pankaj’s deep client relationships and extensive engineering capabilities, combined together with his ability to mentor and grow properly engineering ability will serve Cisco well as we force the subsequent section of engineering management for the business.  when you could be accepted with Pankaj’s carrier company adventure, he previously spent sixteen years in the commercial enterprise area.  over the last 13 years, Pankaj developed and grew Cisco’s carrier company business which today money owed for about 35% of Cisco’s direct product earnings. Pankaj’s leadership in key service issuer areas corresponding to core routing, part routing, SP mobility and SP video has positioned Cisco extremely smartly for the long run. all the way through his tenure Pankaj has delivered a significant number of products to the Cisco portfolio, addressing a wide array of customer needs.  over the last 12 months because the co-leader of engineering, Pankaj has accelerated his involvement in Cisco’s commercial enterprise company, as the intersection points between service provider and commercial enterprise come closer together.

As we dwell focused on being the most fulfilling Cisco for our valued clientele, companions, buyers and personnel nowadays, we in no way lose song of the place we wish to go sooner or later.  we're excited about this evolution in our corporation. Please be a part of us in congratulating Padma, Pankaj and Ned on the next phase of their respective journeys.

John Chambers and Gary Moore

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CNN LOU DOBBS MONEYLINE | killexams.com Real Questions and Pass4sure dumps

here's A RUSH TRANSCRIPT. THIS copy may additionally now not BE IN ITS remaining form and can BE updated.

this is A RUSH TRANSCRIPT. THIS replica might also now not BE IN ITS final form and can BE up-to-date.LOU DOBBS, HOST: Tonight, President Bush puts corporate the usa on note: shape up or face the Justice department.

Democrats accuse the president and Republican lawmakers of being too soft on corporate abuse.

we'll have are living reviews for you from the White condo and Capitol Hill.

WorldCom's CEO sends a letter to the president promising cooperation and reform.

Xerox admits it made a $4-billion mistake however says, nonetheless, it isn't any WorldCom.

we'll have a distinct report there as neatly.

The Arizona wildfire is even better tonight. or not it's damaged through fireplace containment strains. Two further towns tonight are in jeopardy.

And former Enron personnel at the moment are the women of "Playboy" journal.

ANNOUNCER: here's LOU DOBBS MONEYLINE for Friday, June twenty eighth. right here now Lou Dobbs.

DOBBS: respectable night.

President Bush nowadays lashed out against company misbehavior. Mr. Bush referred to groups need to lift the bar and never fudge their numbers. day after today, the president will use his radio address to induce company leaders to clear up their acts.

we now have two studies tonight. We start with Kate Snow on Capitol Hill and Senior White house Correspondent John King.

John.

JOHN KING, CNN SENIOR WHITE residence CORRESPONDENT: neatly, Lou, the president may be speakme about this theme more and more in the days ahead. You mentioned the radio handle the following day. The president will once again urge corporate leaders to reveal accountability, double-determine their accounting practices.

Mr. Bush also will go back and forth to new york metropolis on July 9th, CNN is advised, and convey a speech dedicated entirely to the theme of company responsibility.

The White apartment seizing on this story, making an attempt to get the initiative. Mr. Bush announcing the government is looking at what it might do administratively. he's urging the Congress to take a glance at disclosure rules as well.

Mr. Bush asserting he's concerned about this theme not only as a result of the circumstances of WorldCom and Enron, but he believes it's inflicting a slowdown in client -- a scarcity of purchaser self belief in the stock market and having an affect on the universal U.S. economy.

(begin VIDEO CLIP)

GEORGE W. BUSH, PRESIDENT OF the U.S.: corporate the united states has bought to bear in mind there's a much better calling than making an attempt to fudge the numbers, trying to slide a thousand million here or one billion there and hope nobody notices.,

but you've got a accountability in this country to all the time be above board. We expect excessive requirements in our faculties, we are expecting excessive standards in company the usa as smartly, and i intend to implement the legislations to be sure that there are high specifications.

(end VIDEO CLIP)

KING: The White apartment realizing this is not just a coverage debate but additionally a political debate. Democrats making the case in this midterm election 12 months that the president and his Republican birthday party are guilty for lax law, are too comfortable with huge enterprise. The White apartment says Mr. Bush is determined to get out forward on this one and never let Democrats make that case.

Lou.

DOBBS: John, the president calling upon Congress to behave right here. The White condo has been helping Senator Phil Gramm's efforts to stop reform of accounting and company reform on Capitol Hill. How does this all rectangular off?

KING: smartly, definitely, when you consider that the Enron disclosures and now the WorldCom disclosures, the White condo is asserting that it's asking the SEC Chairman Harvey Pitt to do greater administratively and says it's going to push in the Congress.

however you might be precisely appropriate in that some Democrats on Capitol Hill say there are as a minimum inconsistencies, some say hypocrisies, within the administration's approach. All this now a part of a political debate in this midterm election year as well as a extremely reputable policy debate over simply precisely the place is the role of government in telling company the us the way to govern itself.

And, John, the president is undergoing a colonoscopy this weekend. Any word as to why he is going to be below sedation during that examination?

KING: His doctors suggested this, Lou. The method may also be extremely uncomfortable. Mr. Bush has had two during the past wherein benign polyps were eliminated. His docs say he was sedated at the remaining one.

they say, #1, sedation minimizes discomfort on the patient. And, quantity two, they are saying it makes it possible for then the doctors to do a greater thorough job as a result of, if the affected person is uncomfortable, the medical doctors are likely to rush the technique.

all and sundry right here at the White residence saying here is a really hobbies process for the president to try this. He has no signs in any respect. he's in wonderful health, his medical doctors say.

but he will temporarily switch power to the vp. Mr. Bush says it is a wartime precaution, anticipating Dick Cheney could be appearing president of the united states someplace within the area of one to three hours day after today.

Lou.

DOBBS: ok, John. thanks very a great deal.

Senior White condo Correspondent John King.

Democrats, as John reported, try to profit political abilities from these corporate scandals. nowadays, Senate Majority chief Tom Daschle referred to company corruption is threatening the financial system, and Daschle accused Republicans of backing policies that led to company misbehavior.

For more on the story, i am joined by way of Kate Snow on Capitol Hill.

Kate.

KATE SNOW, CNN CONGRESSIONAL CORRESPONDENT: Lou, Tom Daschle additionally said that he's heard from a lot of CEOs over the closing couple of weeks, and he stated they share his outrage over things like WorldCom. He says they respect as an awful lot as we do, lawmakers do, that, in Daschle's words, there may be bought to be a change within the legal guidelines, the legal guidelines deserve to be reinforced.

He changed into very clear that you simply can't put the only blame on the Bush administration for WorldCom's failure, but he does say that he believes, quote, "a laissez-faire attitude during this administration has helped create the kind of ambiance that exists these days."

(begin VIDEO CLIP)

SEN. TOM DASCHLE (D-SD), SENATE MAJORITY leader: there may be too a great deal executive rules. there is too a good deal govt involvement within the corporate sector. And what we want now's to eradicate government and all of its presence from any oversight obligations.

And, piece by piece, they dismantled the regulatory ambiance that we had and, in enormous measure, created this sense of laissez- faire, of just total unwillingness on the a part of enforcement or regulatory corporations to play a job.

(end VIDEO CLIP)

SNOW: Now, obviously, Democrats are seizing on this concern, hoping that it might profit them some votes this fall in the election.

whereas some Democratic strategists have observed they're now not going to be gleeful about americans dropping jobs, not at all, an additional strategist did say to me this turned into a fortunate ruin, this WorldCom story.

condominium Democratic chief Dick Gephardt being even a little more forceful, a bit more political than Tom Daschle became. He observed -- he cautioned that it was the past eight years of condo Republican handle -- Republican handle of the apartment of Representatives -- that has brought about one of the vital issues because they did nothing about corruption.

And, nowadays, a Republican shot back, invoking bill Clinton's legacy.

(begin VIDEO CLIP)

REP. WILLIAM THOMAS (R), CALIFORNIA: if you wish to discover a mannequin for individuals now not behaving morally -- or the style of saying it is: Do the correct factor even when individuals don't seem to be watching -- I suppose you will locate that the Oval workplace has a whole lot more similarity to the board room than the ground of the house of Representatives.

if you're hunting for someone who set the ethical tone for the decade of the '90s, I do not think you need to seem any farther than the previous president's habits.

(end VIDEO CLIP)

SNOW: And Republicans say they are equally upset about what's took place at WorldCom, they too want action, but they with ease don't see it as a political issue, Lou.

they say that if Democrats are going to are attempting to play up the little man versus the potent during this crusade season, this operative observed, well, perhaps it will work simply as smartly as it did for Al Gore.

Lou.

DOBBS: All appropriate, Kate. One query on this. Tom Daschle, gleeful or now not, regarding the laissez-faire attitude in rolling lower back regulation. The Telecommunications Reform Act of 1996 become signed by bill Clinton. How does that...

SNOW: i am certain Republicans will factor to that too, and they have. They've spoke of, "appear, you can not say that the previous eight years has been totally below Republican control. You had President Clinton within the White condo."

They've made that aspect time and again when this has come up. and that they've additionally said, you know, for a short time -- smartly, the Senate's been in handle now for a short time of the Democrats. What about that?

Lou.

DOBBS: adequate. thank you very a whole lot.

Kate Snow reporting from Capitol Hill.

The parole board in California that has been due to the fact whether to liberate an infamous Manson friend who's serving lifestyles in detention center for her role in killing sprees in 1969 -- Leslie Van Houten become 19 on the time.

here is a reside photo of Leslie Van Houten. She become 19 at the time of those killings. She has faced a parole board 13 times. each and every time, she's been turned down. Her parole again has been turned down.

Let's hear in.

(begin VIDEO CLIP)

UNIDENTIFIED CALIFORNIA PAROLE BOARD MEMBER: She, although, had been arrested for auto theft. They had been no longer interestingly prosecuted. however she did have prior criminal activity in that she became a drug consumer, together with LSD, marijuana, methadrine, mescaline, and benzadrine, and this drug use had been happening for at least a couple of years.

(end VIDEO CLIP)

DOBBS: This, the California Parole Board, denying Leslie Van Houten, a member of the notorious Manson family unit gang, once more for a 14th time being denied a request for parole, and her existence sentence continues.

"surprise" and "outrage," the words used via WorldCom's chief executive officer, John Sidgmore, in a letter to the president these days.

Sidgmore talked about he became bowled over by way of the invention of a $4-billion fraud at his company. He additionally outlined changes he's making in WorldCom's enterprise practices, and, among those, 17,000 layoffs that begun today.

Sidgmore additionally pledged full cooperation with the a number of investigations of WorldCom.

And, in the meantime, a Mississippi judge has issued a restraining order that bars WorldCom, its auditors, and its personnel from destroying files. The choose also stated he would appoint a computer screen to oversee doc retention. An SEC order this week simplest advised that documents be preserved.

yet another accounting scandal at Xerox. Xerox will take out virtually $2 billion of profits that it already suggested. An audit confirmed that Xerox posted these revenues earlier than they were in fact made.

Bruce Francis has the file.

(begin VIDEOTAPE)

BRUCE FRANCIS, CNN CORRESPONDENT (voice-over): Xerox admits that again in the late '90s, it robbed the longer term to make the latest seem improved than it in fact become. The company is revising five years of outcomes.

Xerox needed to restate its financials after settling expenses with the Securities and change commission again in April and paying a $10- million satisfactory.

In a press release, CEO Anne Mulcahy said Xerox these days closes a tough chapter in the business's background. Mulcahy declined to be interviewed for our story.

score the inventory a purchase for the reason that November, Peter Ausnit thinks that Xerox can turn round.

PETER AUSNIT, DEUTSCHE financial institution SECURITIES: We see Xerox as a corporation that can earn a substantial amount of cash over the next couple of years, peculiarly when enterprise conditions normalize.

FRANCIS: but traders, certainly folks that purchased Xerox right through the late '90s, could no longer discover it so easy to overlook Xerox's inaccurate accounting.

As part of its restatement, Xerox now admits it should have booked much less earnings in 1997, 'ninety eight, and '99, a time when the inventory was taking off. however the company insists that the sales -- in this case, gadget leases -- are actual and that the revenue from the late '90s really belongs in 2000, 2001, and past. for instance, 2001 finally ends up searching superior than earlier than by using half one billion dollars.

The base line $1.9 billion may be taken out of revenues already mentioned.

but the writer of "How organizations Lie" says do not cut what Xerox did.

RICHARD SCHROTH, creator, "HOW groups LIE": I don't consider it's a small, little accounting error in any respect. companies like Xerox and others who have been named to the Fortune 100 greatest businesses and other such -- have a accountability to be brazenly careful on these forms of things.

(conclusion VIDEOTAPE)

FRANCIS: neatly, former Xerox auditor KPMG maintains that they have been careful, inserting out a press release these days standing via its prior work with Xerox and calling the copier business's restatement an unbelievable about-face.

Lou, they're on the fence. DOBBS: The auditor now not agreeing with the restatement.

FRANCIS: now not agreeing with the restatement, no longer agreeing with Xerox, no longer agreeing with the SEC, not agreeing with PricewaterhouseCoopers.

DOBBS: And we have now seen loads of room for disagreement, however it does make you wonder how anybody can say they were cautious when there may be an argument of $2 billion.

FRANCIS: high priced selections that cost traders some huge cash, Lou.

DOBBS: And we're, unfortunately, getting used to lots of these choices that can charge traders some huge cash.

Bruce, thanks a whole lot.

stocks closed little modified on the day despite the latest scandal. today marked the conclusion of the 2nd quarter. That quarter noticed main indexes register double-digit losses.

nowadays, the Dow Jones Industrial typical fell more than 26 aspect. The Nasdaq rose pretty much 6 features. The S&P 500 dropped virtually a degree.

Jan Hopkins could have finished market coverage for us in just moments.

Tonight's MONEYLINE quick vote query is concerning the markets. we'd like to be aware of: Do you consider that this inventory market has at last hit backside? that you could cast your vote by means of going to cnn.com/moneyline -- cnn.com/moneyline -- and while you're there, which you can all the time ship us an electronic mail as well. we are going to have the outcomes of tonight's vote later in the broadcast.

We additionally want to take this probability to take a look at your recommendations on corporate scandals. Susan Christie writes in to assert, "With Enron, Arthur Andersen, and now WorldCom, the phrase 'Figures not ever lie, however liars at all times figure,' became on no account extra actual."

John DePetris, "Why should al Qaeda plan greater assaults when we've Enron, WorldCom, Xerox CEOs, CFOs, et cetera, doing what the terrorists would dream of doing? it is destroying the American financial market."

And Brian Scott of Canada says, "Is it any ask yourself that current anti-globalization protesters don't have any faith in the present capital system. All they see are thieves, cheats, and liars whose best pastime is to complement themselves on the fee of traders and personnel."

we are going to have greater of your options later in the broadcast. And, as all the time, which you could e-mail us at moneyline@cnn.com. And we at all times ask that you simply include your identify and address.

Let's flip now to these wildfires raging within the western a part of the nation. a brand new hazard tonight in Arizona. That large hearth close the city of show Low, Arizona, has broken via a containment line, threatening a nearby subdivision.

Thelma Gutierrez has greater on the story for us.

Thelma.

THELMA GUTIERREZ, CNN CORRESPONDENT: Lou, at this time, what's going on is that firefighters are working to establish a fireplace line to push that fire again. The wind has kicked up a little bit in exactly the past few minutes, which is not a superb factor obtainable.

additionally remaining nighttime, the fireplace had moved down the back aspect toward the city of Heber. Firefighters working day and night to try to dangle these hearth lines to save these communities. they have got felt and that they mentioned past nowadays that, if they're able to hold those strains through the day, they'll have an excellent probability of saving the communities.

Now, nowadays and the following day, the crimson move and native officials have begun what they have got called van tours for residents who misplaced their buildings. The residents will most effective have a chance to view their properties. as a result of safety concerns, they will not be allowed to in reality get off and go into their property. And officers have mentioned that on account of the delicate nature of these tours, cameras aren't allowed in.

Now, to date, 419 acres of Ponderosa pines have burned up here in the reveal Low enviornment, and more than 50 p.c of the land that has burned is on the Apache reservation land that has had a devastating affect on tribal individuals. up to now, they say that two sawmills have now closed down. three hundred jobs out here could be lost. the whole estimated price of the bushes they have got lost: $237-million.

(start VIDEO CLIP)

LUCI BENALLY, APACHE TRIBE MEMBER: i am hoping that all and sundry is aware of that now not best do americans within the demonstrate Low and Pinetop areas stand to lose their homes, however our tribe has lost so a whole lot and too much. We're speakme thousands and thousands and thousands and thousands and tens of millions of bucks in an effort to on no account be replaced in our lifetime.

(end VIDEO CLIP)

GUTIERREZ: A spokesperson for the Apache tribe advised me a short while ago that it'll a century earlier than they're in a position to get better from this fireplace, Lou.

DOBBS: Thelma, thank you very much.

Thelma Gutierrez from demonstrate Low, Arizona.

well, officers in Colorado are hoping that calmer weather will help their combat in opposition t wildfires. Two fires close Durango, Colorado, have burned more than 70,000 acres and destroyed dozens of homes. these fires are best a 3rd contained.

in the meantime, an almost a hundred and fifty,000-acre hearth near Denver may still be absolutely beneath manage via Sunday.

coming up tonight, the markets grappling with a surge in earnings restatements by way of corporate the us. we'll investigate the competencies for extra surprises forward.

Wall highway, as soon as the envy of the area. Now lots of the world is questioning our mannequin of capitalism. we are going to have that record for you.

we will verify the problem that the united states faces in sustaining the battle towards terrorism and radical Islamists in our MONEYLINE "Economist" magazine series on American management, New directions.

And Henry Kissinger will be right here to examine the us's peace efforts in the core East.

All of that and more nevertheless forward. live with us.

(industrial damage)

DOBBS: Two foremost enterprises came forward to make big restatements of their prior outcomes this week. The query nobody can reply tonight is how many more restatements are there.

Peter Viles has the story.

(begin VIDEOTAPE)

PETER VILES, CNN CORRESPONDENT (voice-over): As one-two punches go, this turned into an enormously expensive mixture. WorldCom, then Xerox, $6 billion worth of crummy accounting. The number of company revenue and salary restatements had already been rising, spiking an awful lot extra sharply in the contemporary economic downturn than it did in the ultimate one.

So the query traders are asking: is this the top or just the beginning? naturally, the SEC isn't able to declare victory on bogus bookkeeping.

HOWARD SCHILIT, center FOR fiscal analysis & evaluation: The work of the SEC is beginning to decide upon up pace. they have anything like 65 existing investigations. The SEC just bought a large raise in their funds. and that i suppose the power continues to be on the SEC and different regulators to clear up the mess.

VILES: The SEC last nighttime took motion so one can force CEOs to swear, beneath oath, to the accuracy of profits stories, a troublesome step meant to flush out any accounting scandals that are hiding in corporate books.

LYNN TURNER, FORMER SEC CHAIRMAN: Harvey Pitt has to move a step additional and say, "now not most effective do I desire you to signal on the final analysis right here in case you send for your subsequent set of economic statements, but you need to remember if those end up incorrect, we're going to show round and ship you to penitentiary." VILES: that is a superb point, however Harvey Pitt has been there and spoke of that. here's what he referred to this week when asked what happens if these sworn declarations become false?

HARVEY PITT, SEC CHAIRMAN: You go to prison since it's fraud if you certify it and it be false.

(conclusion VIDEOTAPE)

VILES: In light of this hard talk from the SEC, there is a few hypothesis we may also in reality see greater restatements within the coming weeks than we might have otherwise.

corporate the united states basically has six weeks to get its books so as. Then beginning in mid-August CEOs will ought to swear below oath that these books are the fact.

Lou.

DOBBS: it be a disgrace that it be come to this, but Harvey Pitt's thought right here in terms of signing and swearing to those fiscal statements -- it may possibly become the solution here or a big part of it.

VILES: it's a means to make everyone say, "Come ahead. All those that haven't committed accounting fraud, step ahead." It turned into the president's conception initially.

DOBBS: adequate. Pete, I recognize it. thanks.

The scandals sweeping throughout corporate the usa are elevating massive questions in regards to the effectiveness of the mannequin of capitalism, its apply during this nation. international buyers, some of them, are reluctant to put are put their cash during this country, and American accounting practices are being challenged as on no account earlier than.

Kitty Pilgrim has the story.

(begin VIDEOTAPE)

KITTY PILGRIM, CNN CORRESPONDENT (voice-over): For years, the American company mannequin turned into touted because the most useful on earth, U.S. prevalent Accounting principles advanced, and corporate governance probably the most advanced. With debacles at Enron, ImClone, Tyco, and Adelphia dominating U.S. headlines, Europeans are starting to gloat.

"In the usa, all that glitters isn't gold," Deutsche bank's former CEO Rolf Breuer mentioned in a speech this week. however the usa's gadget become golden for a long time and had the numbers to show it. Unemployment lessen than in Europe, capital markets within the U.S. outperforming Europe, bigger productivity numbers, and a strong greenback.

but now the dollar has fallen about 10 percent towards the euro up to now this yr. Markets are foundering, and the enormously touted accounting necessities being reexamined under a congressional microscope, satisfactory to make the White apartment shelter the American method.

ARI FLEISCHER, WHITE condo SPOKESMAN: The president believes that america's free commercial enterprise device is a system this is performed very well for the American people, or not it's resulted in lots comfort, or not it's resulted in a strong culture for the American americans.

PILGRIM: And a glance on the markets indicates, over the last two years, the Dow held up more suitable than stock indexes in Frankfurt, London, and Paris, down 28, 38, and forty two p.c respectively.

Some element out the U.S. company mannequin is always evolving and improving from its missteps.

ROBERT SCHILLER, YALE college ECONOMIST: From decade to decade, we be trained further and further about how to run organisations, but a part of the technique contains experimentation, and experimentation has unpredictable penalties, and some undesirable consequences, and so we are -- from one decade to the subsequent, we have to straighten out these blunders as neatly.

(end VIDEOTAPE)

PILGRIM: So, during the past few months, there were changes in the way distant places companies are operating, and Europeans are now pushing for more unbiased board contributors and superior transparency, and the CEO incentives are also being reexamined. briefly, the becoming pains are being felt all around.

Lou.

DOBBS: but nevertheless free markets and freedom. it's working.

PILGRIM: or not it's working, and...

DOBBS: a bit rough every now and then.

Kitty, thanks plenty.

Kitty Pilgrim.

nevertheless forward here, the last part of our collection with the "Economist" magazine. Tonight, we seem to be at the challenges dealing with the united states in sustaining the battle towards radical Islamism and terror.

Blue chips fizzle on the ultimate day of the 2d quarter. The NASDAQ ends somewhat greater, however a tough quarter it become. we'll be telling you about that.

And the women of Enron display their talents with the assist of "Playboy" journal.

All of that and greater nonetheless forward. dwell with us.

(industrial smash)

DOBBS: shares closed the 2nd quarter little changed on the day despite this newest accounting information from Xerox.

Jan Hopkins has the marketplace for us now.

Jan.

JAN HOPKINS, CNN CORRESPONDENT: Lou, given all of that, it was no longer a bad displaying for shares.

The market in reality brought to yesterday's rally. but the Dow did slip into negative territory simply earlier than the closing bell when the president announced he would transfer power to the vice president right through his colonoscopy tomorrow at Camp David.

For the day, the Dow become down, and it became down for the sixth week in a row. Nasdaq ended the day and week better. The S&P slipped just a little.

Christine Romans is at the new york stock exchange, and Greg Clarkin is on the Nasdaq.

Christine?

CHRISTINE ROMANS, CNN CORRESPONDENT: well, Jan, another unstable day and two-billion shares traded today to close this quarter.

Xerox, as you'll predict, lost 13 p.c because of that restatement, however NIKE soared after mighty fourth-quarter earnings. Auto shares rallied today on hopes for a rebound in June motor vehicle earnings. And Philip Morris won after a horrific week. it be nonetheless down sixteen % this quarter, though. Tyco additionally gaining these days on excessive hopes for its CIT IPO.

however it's been a awful quarter for Tyco, down fifty four %. Take a glance at AOL, parent of this community, AT&T, IBM, and GE, all generally held stocks, all struggling sharp percent losses over the past three months.

Now to the NASDAQ and Greg.

GREG CLARKIN, CNN CORRESPONDENT: And, Christine, relatively quiet day for news in huge identify tech shares.

Take a look returned on the quarter. See how those massive cap know-how shares fared. Take a glance at sun Microsystems down virtually forty three % for the 2d quarter. Intel down pretty much forty percent. Oracle dropping virtually 26 %. You had Cisco with a 17-percent loss. Microsoft down 8.6 percent.

but you are looking to discuss steadiness? How about Dell computing device? It all started the quarter trading at $26.11. It ends the quarter trading at $26.14. That three-penny gain makes Dell desktop the most desirable- performing large cap technology stock for the 2nd quarter.

Jan, again to you.

Thanks, Greg. HOPKINS: The Nasdaq simply comprehensive its worst half-year on listing. it is down 25 p.c for the 12 months thus far, and that i suppose traders don't deserve to be reminded that here's the third yr in a row that the Nasdaq is reduce.

For the S&P, this is the first half-yr in 30 years, a lack of 14 %.

however, Lou, a new quarter begins on Monday.

DOBBS: some thing to look ahead to, as i am sure basically every person is.

Jan, thanks.

smartly, accounting scandals, of path, are the center of attention this week. company misbehavior at WorldCom, Xerox dealing yet another blow to investor self belief. buyers wondering just what on the planet is occurring and what's next.

With me now within the studio is Steve Forbes, the editor of "Forbes," Mark Morrison, editor of "BusinessWeek," and joining us from la, invoice O'Neil. he's the leading man at "buyers enterprise every day."

And or not it's good to have you all here.

Let me begin, if i may, bill, with you. This market behaving, on the very least, badly within the face of dangerous news on profits and scandals. What's occurring, to your judgment?

invoice O'NEIL, "traders enterprise day by day": well, I feel that or not it's the aftermath of the massive tulip bulb craze that went on in '98 and '99. In Holland, everyone purchased tulip bulbs and they went loopy over them, and it all blew up. and that's what took place in excessive-tech and biotech.

DOBBS: i used to be considering extra, invoice, about this week. We discovered concerning the tulips a very long time in the past.

O'NEIL: sure. neatly, this week, the Nasdaq has been going down on account that January 1. it be had three waves down and this closing one is a little steeper, and it undercut a low. however I believe you picked up some brief selling and there's been a whole lot of news. so you're doubtless in along the lows.

The market has in fact shifted to customer shares. So i am no longer so definite that these fallen leaders in the high-tech sector are absolutely elementary for a market it is slowing to regularly get well over time.

DOBBS: Mark, your recommendations?

MARK MORRISON, MANAGING EDITOR, "BUSINESSWEEK": neatly, I suppose the market reacted pretty neatly on the grounds that the extent of the bad information this week. The WorldCom and Xerox announcements had been rather stunning. Yet the market, after that news, acted relatively well, turned into relatively reliable.

and that i believe that in a selective means, the market did might be punish some of the businesses that -- the place accounting questions are nevertheless lingering, those that use...

DOBBS: Amongst people that are...

MORRISON: EBITDA, the ones which have pro forma accounting and have pushed that idea. these -- the market reacted greater in a selective manner than in a ordinary, panicky option to the news.

DOBBS: Steve?

STEVE FORBES, EDITOR, "FORBES": I suppose it's generally right. I think the market is attaining a bottom. I suppose the more pessimism there is, the faster this issue goes to turn round. but one of the things I think it really is weighing on the market, it's not the spate of scandals about companies, but a way that possibly we're not waging this struggle on terror as vigorously as we should still. I think if we went after Iraq and seized those oil fields, I consider you'll see the market actually flow up.

DOBBS: it's pleasing that you'd join those two. We did have polls this week cautioned most effective 1/three of americans trust that we're really successful this war. What do you suppose of that concept, Mark?

MORRISON: I do not think it really is bearing lots in the marketplace right now. I consider that the market is taking possibly some comfort from the incontrovertible fact that the govt and corporate the usa seem to be taking severely this mess this is been going on in bookkeeping and in governance. And that some severe reform goes to come back out of this on the different conclusion. That may additionally take some time, six months or a year from now. although I believe...

DOBBS: can we have time? I imply, it is the exciting query to me. invoice, let me ask you to are available on this. can we truly have time? If we're drawn to restoring investor self belief, will we have time to observe this play out and to peer what number of more are out there?

O'NEIL: I suppose the difficulty is, in the event you move through a severe correction it's extended, you should do something to stimulate the economic system added. or not it's extra like 'seventy three, '74, even a bit bit like' 29. and that i suppose that be sure you speed up some of these tax cuts.

They may still deploy a brand new act to give tax breaks to individuals who start a brand new business. That doesn't mean for all traders, necessarily. but let americans who birth a brand new enterprise simplest need to pay half the common tax, and the owners and founders and employees that personal stock, might be after they promote the stock over the primary 10 years, to only pay half the capital features. this would birth a huge increase in new corporations.

(CROSSTALK)

DOBBS: i am sorry. Go forward, invoice.

O'NEIL: I consider you want some extra stimulus since you're going to come out of this very slowly. you'll come out of it, however you're now not going to come roaring out like nothing ever took place.

DOBBS: Steve, your thoughts on this? greater centered investment tax credits, extra -- I can not think about you resisting that advice.

FORBES: No, my objection could be to the targeting. Why now not simply have an throughout-the-board reduce on the capital gains tax? it truly is what we did within the mid Nineties and it worked. We mustn't overlook that the so-known as booming '90s, the primary half was the worst financial recovery from recession due to the fact the '20s.

DOBBS: you're fully right. it be easy to overlook that. so that you'd want to see it addressed via capital features. How in regards to the idea of a broader investment tax credit?

FORBES: smartly, I feel the key's for tax credit score, instead of attempting to play video games like we did in the early '60s with tax credit score on, tax credit score off. americans have received to consider here is everlasting. And relocating up, as bill suggests, the anemic tax cuts they handed ultimate summer, which are fairly small, make these effective now, that could support too.

DOBBS: well, investors and the audience of this broadcast, there's a real sense that we get here, that americans want to see actual outcomes. they're involved concerning the integrity of the markets. they may be concerned about transparency. They are looking to see true effects from company the us.

Mark, you have been speaking about the EBITDA shares, the pro forma, in case you will, businesses and shares. true earnings -- is there going to be an enduring adjustment here, do you feel, to organizations that simply make funds?

MORRISON: I feel there goes to be. and that's one explanation why I wager i'm a bit little bit of a very good information man about the WorldCom and Xerox news. I feel that this has helped push the administration and company the usa to agree with that this become no longer only a case of a couple of bad apples, but there truly is going to should be some severe apartment cleansing done.

And the option is, what? To form of slide through this episode. and then we go again to business as ordinary. And a yr from now, or two years from now, we've a worse issue.

DOBBS: We're going to return again with bill O'Neill and Mark Morrison and Steve Forbes, and discuss why the surprising urgency about company reform. And we'll come to a decision -- or these three gents will come to a decision no matter if this is the fault of the Democrats or the Republicans. reside with us.

(commercial damage)

DOBBS: We're back with Steve Forbes of "Forbes" magazine and Mark Morrison of "enterprise Week" and bill O'Neil of "traders company daily."

gents, as I talked about at the destroy, we wish to find out whose fault here's, Republicans or Democrats. however first, the query that we're asking our viewers tonight is, has this market bottomed? And, bill, very instantly, has this market on your judgment bottomed?

O'NEIL: I feel it doubtless has. but when it does not, I feel the government must step up and lower some taxes and do a few issues, as a result of there is too lots fear and it be been going on too lengthy. And we don't should have it. it's down in along what must be the backside. And there changed into best the Nasdaq this is been exerting the actual power.

DOBBS: Mark?

MORRISON: I don't see a bottom yet. I believe here's a undergo market and we will have to wait and spot. We're bumping along at low element but valuations are nonetheless excessive. I don't see a true turn yet.

DOBBS: And, Steve, simply moments ago you used an expression, "looking for a backside." How goes the search?

FORBES: I feel if we're no longer at it, we're very close it. I consider traders who like to play timing video games should start to be going again in. I believe we're going to have a rally pretty soon. The extra pessimism there is, the more advantageous the market's going to do.

DOBBS: One would hope that we would now not see a stronger wall of fret confront us than this, or better pessimism. Who can we blame here? Mark, Republicans or Democrats?

MORRISON: actually politicians are partially in charge. They have been on the trip with the traders and with the accountants and with the executives. And all and sundry, even the media, have been on the huge journey in the late '90s, when all these excesses and shortcuts begun.

So, as far as Washington goes, I don't pin the blame on either party. I consider that, absolutely, the Bush folks are having to exchange their tune very dramatically as a result of their view of letting the markets do all the law is not working.

DOBBS: looks like there may be an hobby in some influence other than a market result, in the case of Enron, for example. invoice?

O'NEIL: smartly, the market topped in March of 2000. so you can blame it on either birthday party you are looking to. however human nature is human nature. and every single endure market I've ever seen, every single recession, has a few organizations go bankrupt, a few individuals which are doing some thing dishonest get caught.

And the SEC does a good looking respectable job. at some point they'll seize each one of these individuals. So I do not think that you would be able to blame it on one birthday celebration or the other.

DOBBS: adequate, Steve? FORBES: well, I think if you need to look on the tone of the '90s, it started right at the appropriate, on the White condominium, where the perspective changed into anything goes. if you get caught, spin your means out of it. The handiest component they failed to face up to -- they could withstand everything except temptation. So it all started at the true.

DOBBS: and how about Wall road, the investment bankers, the analysts, all of the business banks assisting these deals?

FORBES: There became an attitude that there are not any greater rules, that you might push the envelope, get to the facet, fall off the facet. The parachute would protect you. And effects was what counted. brief- term results is what counted. And we're having the hangover.

MORRISON: We even have to look at where the cash turned into coming from, from a very refined group of institutional traders who run money for states and pension funds and the rest, who have been simply very chuffed to make investments in the Enrons of the world after they couldn't even be mindful the company or the reports.

(CROSSTALK)

DOBBS: bill, you get the remaining be aware on this thing. Do you like the thought of all these refined cash managers now suing to suitable the market's correction, in case you will?

O'NEIL: smartly, I feel the largest issue, it's unhappy for the general public. Most traders do not really recognize a way to put money into a sound means. They do not truly recognize a way to protect themselves in poorer periods. and that i'm hoping that they'll recognise this and begin trying to analyze and be trained more about the way to choose shares, how to sell them, the way to tackle them, in preference to simply accepting what anyone else says.

DOBBS: That became possibly an appropriate approach after we could watch 25 p.c beneficial properties. or not it's a little distinctive world, as you imply, invoice. invoice O'Neil, thanks for being with us. Mark Morrison, Steve Forbes, recognize it.

coming up subsequent, difficult questions ahead for the us in the conflict towards terrorists and radical Islamists. we will have the MONEYLINE "Economist" journal special document for you subsequent, in "the united states: New directions." dwell with us.

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DOBBS: The continuing MONEYLINE "Economist" magazine collection on "American management: New instructions." Tonight we take a glance at the problem ahead for the U.S. in sustaining this conflict in opposition t terrorism and radical Islamism. we're inspecting even if the usa has the will to head it on my own if integral -- politically, economically and militarily.

(start VIDEOTAPE)

GEORGE W. BUSH, PRESIDENT OF the united states: nowadays, our fellow citizens, our tradition, our very freedom came below assault. DOBBS (voice-over): The president's battle on terrorism has set the stage for a new American period. however's also created challenges to the USA on two fronts: to our political and military power, and to our economic energy.

The president's coalition has been strained and tenuous from the beginning. India, Pakistan, each important participants of that coalition, and both nuclear powers, went to the brink of conflict. France, always uniquely independent in coalition, appears more aligned from time to time with Iraq.

other European international locations, together with our closest ally, Britain, at highest quality seem to be uneasy about U.S. coverage in the center East.

JAMES A. BAKER III, FMR. SECRETARY OF STATE: I think as we movement forward within the battle on terrorism, which is going to be a protracted and strenuous combat, we will endure coalition fatigue. We're suffering it because of the Arab/Israeli conflict, we're struggling it as a result of the concerns between India and Pakistan.

invoice EMMOTT, EDITOR IN CHIEF, "THE ECONOMIST": I consider Colin Powell has it correct. He says that the crucial element is to maintain talking, to tell your allies what you might be doing, why you are doing it. however now not always give them a veto about what you're doing.

BAKER: The most effective and greatest check of a great vigour is the skill to do whatever unilaterally when your country wide hobby requires it.

DOBBS: American leadership during this new era may require the USA to go it alone in accordance with the threats posed with the aid of both Saddam Hussein and Osama bin laden.

EMMOTT: I consider that to make feel of Osama bin weighted down's terrorism, you should anticipate what he'd truly care to do is to emulate Lenin. Lenin was a terrorist who became potent because he got Russia and took over Russia. Osama bin laden is simply a terrorist presently. He can handiest get effective via getting Saudi Arabia or Pakistan or another country.

DOBBS: Kenneth Pollack is a former CIA defense force analyst. Pollack says the time for half-measures in opposition t Saddam Hussein is handed.

KENNETH POLLACK, COUNCIL ON international family members: I feel a full- scale invasion is going to be huge. it's going to be expensive. lots of people are going to lose their lives in it. That referred to, I do not think that it might be practically as expensive as fighting a warfare against Saddam Hussein once he has got nuclear weapons.

DOBBS: the area's simplest superpower, which is additionally the realm's wealthiest nation, will devoid of query be stressed by way of the rising fees of a world battle with elusive enemies. The charge of combating the battle this 12 months will appropriate $seventy six billion.

nonetheless, if the Bush administration wins congressional approval of its total protection funds raise, that finances will nonetheless be near historic lows -- below half what it changed into all over the bloodless conflict, as a percent of the U.S. gross home product.

BAKER: the area has asked lots of U.S. financial engine for a long time. Over the course of the past 10 years we've got been the best true supply of international boom.

UNIDENTIFIED MALE: Our heroes will now open the market.

DOBBS: america's financial power is the basis and engine integral to pressure this war. that is why business scandals like Enron and WorldCom threaten more than simply self belief in the markets and the economic system.

EMMOTT: After the bursting of the inventory market bubble and all of the abuses at Enron and global Crossing and Tyco, and all of these, I suppose america's going to have a bumpy couple of years. right through that period, the usa's confidence in its ability to proceed to fund protection spending and need to go out in the world could get dented every now and then.

DOBBS: The financial costs and political dangers of this battle will be super. however the deserve to win the warfare is essential. And so is the possibility to obtain global peace and prosperity, in keeping with natural American values of democracy and free markets.

EMMOTT: the usa has the possibility to reshape the world in quite a lot of nice techniques in the following couple of years. The query is whether or not it'll continue to have the incentive to do it and permission from the relaxation of the area. My belief is that it'll have each.

(end VIDEOTAPE)

DOBBS: the brand new edition of "The Economist" journal is committed to the altering position of yankee leadership due to the fact that September eleventh. known as "the usa's area on earth," it's on newsstands now.

And coming up next here, the results of our MONEYLINE poll on whether you suppose this market has ultimately hit bottom.

And, how the give way of Enron has given three women the probability to benefit from company failure. stay with us.

(industrial damage)

DOBBS: And this just in to CNN. The Walt Disney company, based on Reuters, will restate its 2000 and 2001 revenue. That in line with SEC filings. The Reuters once more reporting that Disney will restate its salary. And the explanation for that restatement, in line with those SEC filings, is a math error.

Turning now to a different setting up story, explosions heard tonight in the West bank town of Hebron. Palestinian security sources say seventy five p.c of the Palestinian complicated became destroyed. Israeli troops had been outside the complicated for a couple of days now making an attempt to negotiate the give up of Palestinians.

in the meantime, President Bush's center East plan has met with some skepticism on the G-8 summit this week. As you comprehend, G-8 leaders agreeing with the call for Palestinian statehood. however some saying it's as much as the Palestinians to choose their leaders. joining me now to discuss this new initiative is the former Secretary of State Henry Kissinger.

Henry, first rate to have you with us right here.

HENRY KISSINGER, FMR. SECRETARY OF STATE: always good to be with you.

DOBBS: i know you were in Europe when the president put forward the initiative. First, what's your response? Is it a reason behind hope?

KISSINGER: smartly, the president made clear that there is never one plan you could put forward for a negotiation until you have got companions for you to have some self assurance in. and i consider that was an important contribution.

And in the next phase, once some progress is made in that route, I think within the next section, there could be progress in negotiations. and i think what must occur next is that the moderate Arab countries assume some accountability for the domestic adjustments that the president spelled out for the Palestinians.

since the Palestinians aren't able to do it via themselves below current situations. And that means, there could be created a negotiating partner.

DOBBS: Is it your sense that Saudi Arabia, in selected, Egypt, Jordan, have both the ability and the will at the moment to be a positive have an effect on on any reform that the Palestinian Authority must bear to make it feasible for statehood, even on an meantime foundation?

KISSINGER: neatly, they've the potential. and i feel they're constructing the will to do that. likely they'll insist that there's some growth in negotiation -- or some negotiations being conducted. earlier than the complete manner of internal trade in the Palestinian areas is completed. however I believe that they are becoming very stressed with the have an impact on on them of the continuation of suicide bombing and turmoil.

DOBBS: And for the Israelis, the president's insistence that the settlements, the construction of settlements, stop on the West bank and in Gaza, that there be effectively a roll-lower back to the pre-'67 warfare borders. Is that an affordable, and do you think possibly productive, initiative?

KISSINGER: I suppose possibly, sure, I consider it is. I feel the president has called consideration to the incontrovertible fact that you cannot go from right here to a closing contract. You should begin through restoring circumstances by which normal existence can birth once again.

And here is why he's entreated the Israelis to go back when the Palestinians have made their adjustments, to the situations that existed when this complete disaster all started. And additionally to conclusion any new contract undertaking. I suppose here's an inexpensive foundation on which to begin negotiations.

DOBBS: Dr. Henry Kissinger, thank you very a whole lot for being with us, as at all times.

KISSINGER: Pleasure to be on.

DOBBS: Let's take a quick look now at the effects of our MONEYLINE ballot. Tonight's query: do you believe that this inventory market has ultimately hit bottom? Twenty % of you said yes, 80 percent said no. And, while now not scientific, a fair indication. and that i must say that the market doesn't appear to be arguing with the effects of this poll.

arising next, the "Dobbs document." a couple of innovations about the rising political temperature and posturing in Washington about corporate scandals. stay with us.

(business break)

DOBBS: well, after the scandals at Enron, three enterprising former Enron ladies have decided to take advantage of their misfortune through making an attempt to enrich their fortunes, performing in "Playboy" magazine. and that they're cashing in somewhat neatly in a whirlwind media tour which has led them, of course, to new york metropolis. and they are, in case you be interested, appearing in the August situation of "Playboy" magazine.

neatly, Enron, international Crossing, Tyco, ceremony help, Qwest, Adelphia, ImClone methods, now WorldCom -- the Democrats have found a crusade subject, company abuse. The Senate majority leader says the challenge will play in each state this November. Tom Daschle nowadays charged that the Republicans -- quote -- "dismantled the regulatory atmosphere we had and, in significant measure, created the sense of laissez faire," conclusion quote.

Even Al Gore wants to play, asserting at a fund raiser here in long island this week that the president's tax guidelines resemble the outbreak of accounting fraud.

I do not need to be a spoilsport here, however did both Mr. Gore or Senator Daschle note that these multibillion greenback company restatements go back to 1997? That the telecommunications act turned into 1996?

And now, of route, President Bush needs to place them in penal complex and the treasury secretary wants to hang them excessive. George Bush and Paul O'Neill talking about company criminals, now not the Democrats. The president is siccing the Justice branch on the dangerous guys and the SEC is investigating just about every most important enterprise within the nation.

once again, I do not want to be a spoilsport right here, however does the Bush administration neglect that it's been supporting Senator Phil Gramm's efforts to cease accounting and corporate reform on Capitol Hill for months now?

Do the Republicans and the Democrats both understand that the American investing and balloting public is aware that or not it's been six months since Enron went bankrupt, and none of those condo or Senate investigations -- of which there had been a dozen -- have amounted to the rest to this element? That there were no fees introduced towards a single Enron executive?

If the Republicans and the Democrats are thinking about reform now, ultimately, then their movements will have to be as a minimum as energetic as their campaign rhetoric.

this is MONEYLINE for this Friday night. Thanks for being with us and have a extremely pleasing weekend. For everyone here, respectable nighttime from big apple.

TO ORDER A VIDEO OF THIS TRANSCRIPT, PLEASE name 800-CNN-information OR USE OUR relaxed online ORDER kind found AT www.fdch.com

Accuse Bush, Republicans of soppy Stance on company Abuse>


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Puma Biotechnology, Inc. (PBYI) CEO Alan Auerbach on Q2 2018 Results - Earnings Call Transcript | killexams.com real questions and Pass4sure dumps

No result found, try new keyword!As investors are aware, we have an ongoing Phase III trial of neratinib in third-line HER2-positive ... from physicians and also as you know there is a lot of these online videos that physicians post ...

ASCO GU 2019: Results of a 50 Patient Single-Centre Phase II Prospective Trial of Lutetium-177 PSMA-617 Theranostics in mCRPC | killexams.com real questions and Pass4sure dumps

San Francisco, CA (UroToday.com) PSMA is over-expressed in all prostate tissue, including prostatic carcinoma. Lutetium-177 (177Lu)-PSMA617 (LuPSMA) is a small radiolabeled molecule which binds to PSMA and delivers a dose of β radiation. Lutetium-177 is a good partner to help deliver the radiation because of the short range β radiation (maximal tissue penetration of <2mm), thereby decreasing the potential collateral damage to nearby organs. 

The authors of this study have previously reported on their experience of 30 men with metastatic CRPC treated in a single-center phase II prospective trial of LuPSMA.1 This abstract represents an updated analysis of an extended cohort of 50 patients.  

In this phase II trial, 50 men with PSMA-avid (defined as high PSMA expression in at least one site of metastatic disease with > 1.5 SUV of the liver) mCRPC who had progressed after standard therapies (including docetaxel and androgen-axis targeted therapies) received up to 4 cycles of LuPSMA every 6 weeks. The full protocol can be seen below: ResultsSchema_177LuPSMA.png

The primary endpoints were PSA response (according to PCWG2 criteria) and toxicity (according to CTCAE v4). Secondary endpoints included imaging response, PSA PFS and OS. 

75 men were screened to identify 50 patients eligible for treatment. Median PSA doubling time was 2.6 months. The majority of patients had received prior docetaxel (84%), cabazitaxel (48%), and abiraterone and/or enzalutamide (90%). Full demographic info is seen below:PatientDemographicInfo.png

These men are heavily pretreated mCRPC patients with limited alternative options. The mean administered radioactivity was 7.5 GBq/cycle.  

In terms of response, PSA decline ≥ 50% was achieved in 32 of 50 patients (64%, 95% CI 50-77%), including 22 patients (44%, 95% CI 30-59%) with a PSA decline ≥ 80%. Best PSA response is depicted here: BestPSAResponse_ASCOGU.png

27 patients had measurable soft tissue at baseline and 56% of these patients had a partial or complete response by RECIST 1.1 criteria.  

Median PSA PFS was 6.9 months (95% CI 6.0-8.7) and median OS was 13.3 months (95% CI 10.5-18.0). Upon subsequent progression, further LuPSMA was administered to 14 patients (median 2 cycles commencing 359 days from enrolment); PSA ≥ 50% response occurred in 9 patients (64%), indicating the option for retreatment. 

The PFS KM curve:PFS_KM_Curve.pngPatients who had a >= 50% response had a PFS of 8.3 months. 

OS K-M curve seen below:OS_KM_Curve.pngMen who had a >= 50% PSA response had a median OS of 18 months.  

Overall, LuPSMA was well tolerated. The most common toxicities attributed to LuPSMA were transient G1-2 dry mouth in 68%, G1-2 nausea in 48%, and G1-2 fatigue in 36%. G3-4 toxicities attributed to LuPSMA were infrequent with thrombocytopenia in 10% and anemia in 10%.  

Using this expanded 50 patient cohort confirms high response rates and low toxicity with LuPSMA in men who had progressed after standard therapies. In patients who subsequently progressed and were administered further LuPSMA, high response rates were also observed, indicating that this treatment can be repeated with significant response. These results have provided the basis for randomized controlled trials currently underway – the ANZUP/PCFA TheraP trial (Lutetium-PSMA vs. cabazitaxel) and the Endocyte VISION trial.  

Presented By: Michael Hofman, FRACP, MBBS, nuclear medicine physician in the Centre for Cancer Imaging at the Peter MacCallum Cancer in Melbourne

Written by: Thenappan Chandrasekar, MD, Clinical Instructor, Thomas Jefferson University; Twitter: @tchandra_uromd, @JEFFUrology at the 2019 American Society of Clinical Oncology Genitourinary Cancers Symposium, (ASCO GU) #GU19, February 14-16, 2019 - San Francisco, CA

References: 

  • Hofman MS, Violet J, Hicks RJ, Ferdinandus J, Thang SP, Akhurst T, Iravani A, Kong G, Ravi Kumar A, Murphy DG, Eu P, Jackson P, Scalzo M, Williams SG, Sandhu S. [177Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, phase 2 study. Lancet Oncol. 2018 Jun;19(6):825-833. doi: 10.1016/S1470-2045(18)30198-0. Epub 2018 May 8. 

  • Fujifilm X-A5 Unveiled as Smallest & Lightest X Series Mirrorless Digital Camera | killexams.com real questions and Pass4sure dumps

    FUJIFILM unveiled today the Fujifilm X-A5 as the smallest and lightest X Series zoom lens kit mirrorless digital camera featuring recently developed sensor and color reproduction technology.

    Sporting a 24.2MP APS-C sensor with 1.5x crop factor that features a phase detection autofocus system and Fujifilm's latest image processing engine capable of offering processing speeds of up to 1.5 times faster than previous models, Fujifilm X-A5 offers higher ISO sensitivity of ISO12800, more accurate scene recognition in SR+ AUTO mode, 4K movie recording, a 180 degree tilting rear LCD with touch screen, and Bluetooth support.

    "Combined with Fujifilm's renowned outstanding image quality with the company's proprietary color reproduction technology, the X-A5 is compact, stylish and portable making it the ideal companion for everyday photography," says Fujifilm in today's announcement. "The X-A5 combines a newly developed 24.2 megapixel APS-C sensor with the image processing engine to achieve Fujifilm's renowned photo quality."

    The first X-A Series model to feature phase detection pixels

    Fujifilm X-A5 is also Fujifilm's first X-A Series digital camera to feature phase detection pixels, which can be found only in the high-end X Series models. Also, Fujifilm X-A5 includes the first electric-powered zoom lens for the X Mount, the FUJINON XC 15-45mm (23-68mm in 35mm format) f/3.5-5.6 OIS PZ, which Fujifilm says it's perfect for photographing human subjects, but also for capturing those "can't-be-missed" moments on your holidays.

    Also noteworthy is that Fujifilm X-A5 integrates an Intelligent Hybrid AF that's twice as fast as in previous models so you won't miss any crucial photographic moment, as well 11 variations of Fujifilm's unique Film Simulation Modes, including the new "HDR Art" and "Fog Remove." Last but not least, Fujifilm X-A5 incorporate the latest Bluetooth Low Energy technology for easy pairing with Fujifilm's Camera Remote app for iOS and Android.

    Fujifilm X-A5 is also compatible with the FUJIFILM Instax SHARE SP-3 printer and offers a High-Speed HD Video function and new 4K video capabilities. A new battery was included as well in this model, promising to allow you to shoot up to 450 photos per single battery charge. Fujifilm X-A5 weighs only 496g, which makes it the perfect camera for travel photographers. Fujifilm X-A5 costs $600 USD and it's available in Brown, Silver, and Pink colors.

    Fujifilm X-A5

    Fujifilm X-A5

    Fujifilm X-A5

    Fujifilm X-A5



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    NI [1 Certification Exam(s) ]
    NIELIT [1 Certification Exam(s) ]
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    RSA [15 Certification Exam(s) ]
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    SASInstitute [15 Certification Exam(s) ]
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    SCO [10 Certification Exam(s) ]
    SCP [6 Certification Exam(s) ]
    SDI [3 Certification Exam(s) ]
    See-Beyond [1 Certification Exam(s) ]
    Siemens [1 Certification Exam(s) ]
    Snia [7 Certification Exam(s) ]
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    Tibco [18 Certification Exam(s) ]
    Trainers [3 Certification Exam(s) ]
    Trend [1 Certification Exam(s) ]
    TruSecure [1 Certification Exam(s) ]
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    VCE [6 Certification Exam(s) ]
    Veeam [2 Certification Exam(s) ]
    Veritas [33 Certification Exam(s) ]
    Vmware [58 Certification Exam(s) ]
    Wonderlic [2 Certification Exam(s) ]
    Worldatwork [2 Certification Exam(s) ]
    XML-Master [3 Certification Exam(s) ]
    Zend [6 Certification Exam(s) ]





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    Cisco 644-344 Exam (SP Video Phase III Wireline) Detailed Information



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