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250-511 - Administration of Symantec(TM) Data Loss(R) Prevention 11 - Dump Information

Vendor : Symantec
Exam Code : 250-511
Exam Name : Administration of Symantec(TM) Data Loss(R) Prevention 11
Questions and Answers : 176 Q & A
Updated On : April 24, 2019
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250-511 Questions and Answers

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250-511 Administration of Symantec(TM) Data Loss(R) Prevention 11

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250-511 exam Dumps Source : Administration of Symantec(TM) Data Loss(R) Prevention 11

Test Code : 250-511
Test Name : Administration of Symantec(TM) Data Loss(R) Prevention 11
Vendor Name : Symantec
Q&A : 176 Real Questions

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Symantec Administration of Symantec(TM) Data

Symantec Introduces New period of advanced possibility insurance policy | killexams.com Real Questions and Pass4sure dumps

MOUNTAIN VIEW, Calif.--(business WIRE)--Symantec Corp. (NASDAQ:SYMC), the global leader in cyber safety, today added Symantec advanced chance insurance policy (ATP), the first solution that can notice and remediate superior threats across manage facets, from a single console with only a click, all and not using a new endpoint agents to set up.

advanced threats, reminiscent of ransomware, far flung entry trojans, advanced persistent threats (APTs) and 0 day attacks, are on the upward thrust and protection authorities can now not rely on the use of particular person aspect products at each and every manage element to cease them. The procedure of uncovering risk data across endpoint, community and electronic mail gateways is manual and time-drinking, which offers attackers an side. Symantec ATP correlates suspicious exercise throughout all handle aspects and prioritizes the activities that pose probably the most risk to an organization. once a vital risk is recognized, it will possibly now be rapidly contained and new instances may also be blocked.

Symantec ATP makes it possible for valued clientele to:

  • discover a full range of threats from APTs to zero day assaults throughout endpoint, community and electronic mail, with pass-handle factor detection and environmental search
  • Prioritize what concerns most by way of correlating the possibility intelligence from throughout local control facets with all that Symantec sees globally through its large telemetry
  • Remediate the threats speedy through containment of endpoints and blocking off new cases throughout manage aspects, with one click, from a single console
  • Leverage latest investments in Symantec Endpoint safety and e mail safety.cloud, with out deploying any new endpoint brokers
  • “security gurus are constantly on their toes trying to display screen and stop the subsequent cyber-attack,” mentioned Michael A. Brown, president and CEO, Symantec. “We’re relocating the trade forward with Symantec advanced danger protection with the aid of giving clients an entire photo of their whole business from a single console. Now they could clear out the noise and quickly find and remediate an assault.”

    cutting back the noise for customers with Symantec ATP occurs in a couple of methods. First, Symantec’s big world possibility intelligence combined with local customer records means companies have a more correct view of which threats pose the greatest risk interior their infrastructure. moreover, Symantec ATP comprises Symantec CynicTM, a brand new cloud-based sandboxing and payload detonation carrier to find and prioritize nowadays’s most superior threats. It additionally includes SynapseTM, a pass-control aspect correlation ability that collects suspicious activity across endpoints, networks and e-mail to prioritize people who are of premiere possibility to the firm.

    “Our new Synapse and Cynic technologies work together to supply up to 30 percent superior detection than latest products out there1,” said Balaji Yelamanchili, executive vice president and accepted manager of enterprise security company, Symantec. “earlier than, a security professional would need to manually determine to peer if a suspicious file became appropriately blocked. With our new applied sciences constructed into Symantec ATP, we do the legwork for shoppers, cutting down on their search and remediation time.”

    “The regular business uses 75 distinctive protection products,” Yelamanchili added. “That overload creates possibility for attackers because it slows down detection. Symantec ATP makes it possible for security professionals to click on as soon as and remediate all over across all three control features.”

    Symantec ATP enhances present installations of SymantecTM Endpoint coverage and e mail protection.cloud devoid of requiring any new endpoint brokers. This enables consumers to installation a brand new installing of Symantec ATP in under an hour and seek attacks in minutes. The product can also export its wealthy intelligence into third birthday celebration security incident experience managers (SIEMs). As Symantec ATP evolves, the enterprise plans to open it up to third party technology partners, together with firewall and different security product vendors, allowing consumers to increase the cost of their current investments.

    aiding costs

  • “Securing a big pan-European stock exchange is high stakes and our IPO in 2014 introduced an enormous diploma of complexity to securing our facts. as the world has viewed, one technical glitch can rock the markets and cause fiscal, criminal and reputational harm. Euronext became to market-chief Symantec to at ease its infrastructure and signed on to look at various an early version of Symantec’s superior probability insurance plan. Already it’s featuring improved visibility into what’s happening on Euronext’s endpoints; and doing it in a less complicated, quicker more efficient way. because of this, Euronext has prioritised and reduced the variety of talents safety incidents,” noted Marc green, Head of chance and Vulnerability management, Euronext.
  • “in reality, going forward, greater prevention, detection, response and prediction capabilities are all crucial to contend with every kind of attacks, ‘advanced’ or now not. in addition, these should still no longer be viewed as siloed capabilities; rather, they may still work intelligently together as an built-in, adaptive device to constitute an entire insurance plan system for advanced threats.” (supply: Gartner, Designing an Adaptive security architecture for insurance policy From superior attacks 12 February 2014, Gartner Foundational 19 November 2014)
  • “As corporations' security estates become greater complicated, in response to a dynamic danger panorama, CISOs demand a platform that integrates and manages their safety operations. in a similar way, to address competencies shortages, they need a mechanism that automates as an awful lot of their safety operations as feasible, and in specific detects and remediates threats right away,” mentioned Duncan Brown, analysis Director, European protection practice, IDC.
  • “Our strategic relationship with Symantec has bought an extra raise with the addition of the Symantec superior probability protection. at the present time of cyber threats, we firmly agree with that ATP will tremendously raise valued clientele’ defenses by means of embedding sophisticated possibility detection and remediation capabilities into their current security portfolio. by using leveraging Wipro’s commercial enterprise protection solutions’ potential and Symantec’s effective expertise prowess, we are expecting to considerably enhance our shoppers’ confidence in their Cyber insurance plan and risk management approach,” referred to Sheetal Mehta, VP & international Head – commercial enterprise safety options, Wipro.
  • “In nowadays’s dynamic world, corporations, greater than ever, are challenged by way of safety requirements because the facts resides in public, inner most and virtual environments. The truth of the BYOD phenomenon internal corporations have made facts possibility management the entire extra vital,” referred to Kalyan Kumar, SVP & Chief Technologist, HCL technologies. “In this kind of state of affairs, Symantec advanced threat protection is a state-of–the-paintings answer that not handiest acts as an early warning device however allows consumers to take full advantage of Symantec’s vast amounts of threat intelligence to aid prioritize the incidents that aren’t caught by way of different factor products across the enterprise IT atmosphere. It’s precisely what our purchasers are seeking – a simple technique to manage and forestall the next mega breach.”
  • Pricing and Availability

    Symantec superior chance coverage might be obtainable by using conclusion of calendar 12 months 2015.starting MSRP is $40 per person yearly to at ease one manage pointStarting MSRP is $60 per person yearly to cozy two handle pointsStarting MSRP is $70 per person annually to relaxed three manage elements

    About Symantec

    Symantec agency (NASDAQ:SYMC) is the global leader in cybersecurity. operating one of the most world’s largest cyber intelligence networks, we see more threats, and give protection to greater shoppers from the subsequent era of assaults. We assist organizations, governments and individuals relaxed their most crucial records at any place it lives.

    forward-looking STATEMENTS: Any ahead-looking indication of plans for items is preliminary and all future liberate dates are tentative and are discipline to change. Any future free up of the product or planned modifications to product ability, functionality, or function are discipline to ongoing contrast through Symantec, and might or might also not be applied and should not be considered firm commitments by Symantec and may not be relied upon in making procuring selections.

    1 supply: Miercom, Symantec advanced chance insurance policy: network, April 2015. http://miercom.com/pdf/experiences/20150218.pdf

    CrowdStrike vs Symantec: properly EDR options in comparison | killexams.com Real Questions and Pass4sure dumps

    Most contemporary products Articles

    Endpoint security products from CrowdStrike and Symantec both made eSecurity Planet's record of top conclusion point detection and response (EDR) solutions – and while each and every product has an awful lot to offer business shoppers, there are key variations between them. What follows an analysis of every solution's key aspects, in addition to some strengths and weaknesses.

    The base line

    each solutions are rated highly through clients in addition to business analysts. CrowdStrike's cloud structure makes deployment strangely short and easy, notwithstanding the incontrovertible fact that or not it's a long way less beneficial offline makes it unsuitable for air-gapped networks. Symantec offers each an on-premises solution and a cloud-primarily based one, featuring a wider range of alternatives for shoppers – but it's frequently considered as being greater complicated to manage than its opponents.

    CrowdStrike EDR Highlights

    Overview: CrowdStrike Falcon insight leverages signatureless AI and indicator-of-assault (IOA) based mostly probability prevention to offer protection to users from all kinds of cyberattacks. Falcon offers contextualized probability intelligence with particulars on the hazard, and a five-second search tool allows for teams to discover and investigate current and historic possibility exercise by means of going lower back one 2nd, someday or one year of pastime. The solution’s cloud-based mostly architecture is designed to give fast response without placing any stress on purchasers' endpoints.

    recent traits: improvements over the past twelve months encompass:

  • a tool manage characteristic for visibility and administration of USB instruments
  • A Vulnerability assessment characteristic, opting for vulnerabilities and missing updates on endpoints through immediately monitoring and examining patches on each and every system
  • Mapping of detection to a framework based on MITRE ATT&CK to speed up figuring out, triage and response
  • true-time response movements
  • Docker support, allowing the setting up of the Falcon agent on hosts operating the Docker container platform so the host can be secured while consumers use Docker
  • elevated integration of the Falcon OverWatch managed detection and response carrier
  • https://o1.qnsr.com/log/p.gif?;n=203;c=204660769;s=9477;x=7936;f=201812281319310;u=j;z=TIMESTAMP;a=20394213;e=i

    Analysts' take: Gartner says the combination of Falcon OverWatch with Falcon perception EDR is certainly compelling for businesses with small or no SOC teams. The Falcon insight EDR agent offers parity throughout home windows, Mac OS and Linux systems, and valued clientele document essential and straightforward deployments, in part as a result of the answer's cloud structure. nevertheless, the research firm says Falcon's EDR functionality requires knowledgeable technical personnel to make use of, and its offline insurance plan is vastly superior when related to the cloud-based Falcon platform, making it unsuitable for air-gapped (secure, remoted) networks.

    Symantec EDR Highlights

    Overview: Symantec EDR uses behavioral evaluation at the endpoint and AI-based mostly analytics in the cloud to discover superior assaults. The answer provides a comprehensive set of detection, investigation and remediation capabilities for all tiers of investigators, together with automatic investigation playbooks and user conduct analytics. Incident responders can immediately search, determine and comprise impacted endpoints whereas investigating threats the usage of a decision of on-premises and cloud-primarily based sandboxing.

    recent tendencies: improvements over the ultimate 12 months include:

  • assist for targeted assault Analytics (TAA), leveraging AI algorithms to become aware of suspicious undertaking and rising threats in Symantec Endpoint insurance plan information accumulated and correlated in a enormous records lake
  • guide for MITRE ATT&CK tactics and ideas and MITRE Cyber Analytics, enabling investigators to look and filter hobbies and incidents by MITRE ATT&CK tactics with a purpose to map movements to the ATT&CK matrix
  • brought more than a dozen detections from the MITRE Cyber Analytics Repository (motor vehicle) as computerized investigation playbooks
  • Analysts' take: Gartner says Symantec is the primary seller to offer malware coverage, EDR, device hardening and deception capabilities in a single agent, and its large deployment throughout a really tremendous population of both client and company endpoints offers it a very huge view into the chance landscape throughout many verticals. still, the research company says Symantec is perceived as extra complex and useful resource-intensive to manipulate than its competitors, and its managed safety capabilities are extra expensive than those from more recent providers.

    EDR Product rankings

    listed here are eSecurity Planet's scores of every solution's key facets.

    performance: shoppers of each vendors record solid performance, with minimal have an effect on on endpoints. essentially the most fresh Forrester Wave file on EDR options gave CrowdStrike the optimum ranking of all EDR companies proven – 4.fifty six out of five – and gave Symantec a score of two.72 out of five. The rating is based on a variety of criteria, including configurability, agent effectiveness, forensic capabilities, deployment alternatives and response movements.

    Detection and response: In fresh checking out, Forrester rated CrowdStrike's detection capabilities at four.eight out of 5, and its response capabilities at four.6 out of 5. Symantec's detection capabilities were rated at 2.0 out of 5, and its response capabilities at four.2 out of 5. Symantec shoppers report stronger possibility detection and containment with the addition of computer getting to know and other superior anti-malware facets, Gartner noted.

    cost: while CrowdStrike is extra expensive than many other options, cloud statistics storage and managed detection and response are protected. Symantec presents managed features, however those features are greater high priced than those from other providers.

    Implementation and management: CrowdStrike's cloud architecture makes deployment certainly effortless, whatever clients time and again cite in studies. Symantec presents each cloud-primarily based and on-premises alternate options, making it more desirable suited for hybrid environments. both options require expert technical personnel to manage, although managed detection and response services can be found.

    assist: Gartner says Symantec purchasers file inconsistent assist experiences, even when giant organizations are offered with committed help personnel. nevertheless, some reviewers spoke of the identical of CrowdStrike's tech aid.

    Cloud features: both organizations present cloud-based mostly options, besides the fact that children CrowdStrike's offering is purely cloud-based, giving Symantec the part in hybrid environments.

    CrowdStrike vs Symantec 

    consumer studies

    Gartner Peer Insights clients give CrowdStrike Falcon an average rating of four.6 out of 5, with Symantec EDR following at a standard of four.0 stars out of 5. IT imperative Station clients supply CrowdStrike 4.0 stars out of 5, and Symantec four.1 out of 5.

    CrowdStrike reviewers repeatedly stated the product’s ease of deployment, calling it "short and easy to install" and reporting that "the sensor is truly lightweight and has no longer been considerable when operating on even aid-limited computer systems." different reviewers wrote that "the hobbies administration of this answer is manageable," and that CrowdStrike has "a different proposition with their cloud-primarily based method as neatly because the research group."

    Symantec reviewers said that "implementation changed into effortless." They referred to "short whitelisting and blacklisting and informative reporting" as key advantages, including that the answer "has provided visibility insights that we were no longer receiving from other items." yet another reviewer pointed out the product "matches very neatly with our existing strategies and strategies," calling it "a superb product to give protection to your environment."

    study more experiences written via users of CrowdStrike and Symantec.


    The CrowdStrike Falcon platform is absolutely cloud-based mostly, allowing it to be deployed within hours, and supports windows, Mac and Linux programs.

    Symantec EDR presents cloud, on-premises and hybrid deployment models, and supports windows, Mac and Linux methods.


    CrowdStrike Falcon insight is purchasable for an annual subscription payment per endpoint, with a free trial purchasable. AWS gives some pricing information.

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    Symantec warns of China-based espionage campaign targeting satellites | killexams.com Real Questions and Pass4sure dumps

    A China-based mostly cyber group is carrying out an extensive hacking campaign by way of focused on satellite, telecom and protection organizations in the united states and Southeast Asia, a U.S. cybersecurity company warned this week.

    The purpose of the hacking group, called "Thrip," is probably going countrywide cyber espionage, safety researchers at Symantec Corp. mentioned on Tuesday.

    "Thrip’s attack on telecoms and satellite tv for pc operators exposes the probability that the attackers could intercept or even alter communications traffic from enterprises and consumers," Symantec spoke of in a press release, including that the most stressful discovery is an try to handle satellites by means of infecting linked computer systems with malware.


    "The assault community gave the impression to be principally drawn to the operational aspect of the company, hunting for and infecting computer systems running application that screens and controls satellites. this suggests to us that Thrip’s factors go beyond spying and can additionally encompass disruption," Symantec wrote in a separate blog publish.

    Satellites play a important function in telecommunications, receiving and transmitting phone and information superhighway alerts as well as mapping and geolocation information.

    Symantec observed in Tuesday's observation that it has tracked Thrip in view that 2013 and currently followed that the cyber group looks to have "found out new tools and concepts used via the community in this most fresh set of attacks."

    The possibility of the more suitable hacking toolbox is extra compounded by way of Thrip's means to reside smartly hidden.

    "They function very quietly, blending in to networks, and are most effective found the use of artificial intelligence that may determine and flag their actions," Symantec Chief government Greg Clark noted in a statement.

    The business says it found out the new attacks through its artificial intelligence-based targeted assault Analytics, which helped the researchers spot the malicious habits that become hiding in reputable IT administration equipment.

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    BioCryst Reports Fourth Quarter and Full Year 2018 Financial Results | killexams.com real questions and Pass4sure dumps

    —APeX-2 24-week safety and efficacy data of once-daily oral BCX7353 for prophylaxis of hereditary angioedema (HAE) attacks on-track for Q2 2019—

    —Full ZENITH-1 results confirm safety and efficacy profile of oral 750 mg BCX7353 for upcoming Phase 3 trial in acute treatment of HAE—

    —Oral Factor D inhibitor, BCX9930, advancing to Phase 1 development for complement-mediated diseases—

    —Recent $100 million debt financing increases financial flexibility—

    RESEARCH TRIANGLE PARK, N.C., March 04, 2019 (GLOBE NEWSWIRE) -- BioCryst Pharmaceuticals, Inc. (BCRX) today announced financial results for the fourth quarter and full year ended December 31, 2018, and provided a corporate update.

    “In a year with many transformative milestones for BioCryst, it has been exciting to see so much progress already in the first two months of the year. The strong Phase 2 clinical data from our now-completed ZENITH-1 trial propels our BCX7353 acute program for HAE into Phase 3 development. With the very favorable preclinical profile of BCX9930, another novel BioCryst-invented oral drug for rare diseases, we are advancing that program into the clinic in the second quarter for the treatment of complement-mediated diseases. We also added further rare disease expertise to our board and increased our financial flexibility with a $100 million debt agreement,” said Jon Stonehouse, president and chief executive officer of BioCryst.

    “We remain on-track for the readout of our APeX-2 trial next quarter, and an NDA filing of BCX7353 for HAE prophylaxis by the end of the year. We are thoughtfully building our commercial leadership and infrastructure to execute a successful launch that meets the urgent demand for a once-daily oral therapy that will allow HAE patients to live a more normal life,” Stonehouse added.

    Recent Milestones

  • The company has dosed the first patients in its APeX-J trial in Japan, designed to support potential Japanese approval of BCX7353 for the prevention of HAE attacks. 
  • On March 4, 2019, the company announced that it is advancing BCX9930, an oral Factor D inhibitor, into Phase 1 clinical development in the second quarter of 2019 for the treatment of complement-mediated diseases.
  • On February 23, 2019, the company announced data from the completed ZENITH-1 trial (including the 250 mg and 500 mg dose cohorts) of BCX7353 for the acute treatment of HAE attacks at the annual meeting of the American Academy of Allergy, Asthma & Immunology. The company plans to commence a Phase 3 trial, ZENITH-2, in the summer of 2019. 
  • On February 6, 2019, the company announced it had entered into a $100 million secured credit facility with MidCap Financial Trust pursuant to the terms and conditions of an amended and restated credit and security agreement. 
  • On January 4, 2019, the company announced it had appointed Steve Aselage to its board of directors. 
  • On January 2, 2019, the company announced the dosing of the first subject in a randomized, placebo-controlled Phase 1 clinical trial to evaluate intravenous galidesivir, its investigational broad-spectrum antiviral drug, in healthy volunteers.
  • Fourth Quarter 2018 Corporate Developments

  • On November 20, 2018, BioCryst announced that it had appointed Theresa Heggie to its board of directors. 
  • On November 16, 2018, BioCryst presented data that showed an oral formulation of BCX7353 was rapidly absorbed and exhibited a long half-life, two important characteristics of desired new acute treatments for HAE attacks, at the annual scientific meeting of the American College of Allergy, Asthma & Immunology.
  • Upcoming Key Milestones

    HAE Program – BCX7353

  • Report 24-week safety and efficacy results from the APeX-2 clinical trial (Q2 2019) 
  • Begin a Phase 3 clinical trial of oral BCX7353 for the acute treatment of HAE (Summer 2019) 
  • File a new drug application (NDA) for oral BCX7353 for the prevention of HAE attacks with the U.S. Food and Drug Administration (FDA) (Q4 2019)
  • Complement Factor D Inhibitor Program – BCX9930

  • Begin a Phase 1 trial of BCX9930, an oral Factor D inhibitor for treatment of complement-mediated diseases, in healthy subjects (Q2 2019) 
  • Report Phase 1 results (Q4 2019)
  • ALK-2 Inhibitor Program – BCX9250

  • Begin a Phase 1 clinical trial of BCX9250, an oral ALK-2 kinase inhibitor for treatment of fibrodysplasia ossificans progressiva, in healthy subjects (2H 2019)
  • Fourth Quarter 2018 Financial Results

    For the three months ended December 31, 2018, total revenues were $2.7 million, compared to $3.9 million in the fourth quarter of 2017. The decrease was primarily due to a reduction of royalty revenue associated with differences in the onset and severity of the influenza seasons between the two periods. This decrease was partially offset by increased revenue from government contracts for galidesivir development, which was higher in the fourth quarter of 2018.

    Research and development (R&D) expenses for the fourth quarter of 2018 increased to $23.4 million from $16.9 million in the fourth quarter of 2017, primarily due to increased spending on the company’s HAE and preclinical programs.

    General and administrative (G&A) expenses for the fourth quarter of 2018 decreased slightly to $4.5 million, compared to $4.7 million in the fourth quarter of 2017. The decrease was primarily due to the lack of merger-related costs in the fourth quarter of 2018 associated with the company’s terminated merger with Idera Pharmaceuticals, Inc. (Idera). The decrease in G&A expense due to the lack of merger expenses was largely offset by higher commercial and medical affairs expenses in the fourth quarter of 2018.

    Interest expense was $2.4 million in the fourth quarter of 2018, compared to $2.2 million in the fourth quarter of 2017 and was associated with enhancing our secured credit facility in July 2018.

    Net loss for the fourth quarter of 2018 was $27.4 million, or $0.25 per share, compared to a net loss of $19.5 million, or $0.20 per share, for the fourth quarter of 2017. 

    Cash, cash equivalents and investments totaled $128.4 million at December 31, 2018, and reflect a decrease from $159.0 million at December 31, 2017. Cash and investments reflect the proceeds from a July 2018 enhancement to our secured credit facility and an August 2018 public equity offering, offset by normal operating expenses and merger-related costs incurred in the 12-month period. Operating cash use for the fourth quarter of 2018 was $22.6 million, and for the full year of 2018 was $93.4 million.

    On February 6, 2019, the company announced it had entered into a $100 million secured credit facility with MidCap Financial Trust which further enhanced the company’s cash position with $20 million of immediate additional non-dilutive capital and provided additional financial flexibility by providing the ability to draw another $50 million of milestone-based non-dilutive capital.

    Story continues

    Full Year 2018 Financial Results

    For the full year ended December 31, 2018, total revenues were $20.7 million, compared to $25.2 million in the full year ended December 31, 2017. The decrease in revenue was primarily associated with infrequent revenue events that occurred in 2017 that did not recur in 2018, as well as a $2.1 million decrease in revenue associated with development activities under U.S. government contracts in 2018. The non-recurring 2017 events were the recognition of $4.1 million of royalty revenue from Japanese government stockpiling of RAPIACTA® and the recognition of $1.5 million of peramivir product sales from the company’s commercial partner, Green Cross Corporation. These decreases were partially offset by a $5.0 million milestone associated with the European Medicines Agency’s (EMA) approval of peramivir (ALPIVABTM) recognized in the second quarter of 2018.

    R&D expenses in 2018 increased to $84.9 million from $67.0 million in 2017, primarily due to increased spending on our HAE and preclinical programs. These increases were partially offset by a decrease in the company’s peramivir and galidesivir development spending in 2018.

    G&A expenses in 2018 increased to $29.5 million, compared to $13.9 million in 2017. The increase was primarily due to approximately $11 million of merger-related costs associated with the company’s terminated merger with Idera and a $4.9 million reserve for collectability of the EMA approval milestone of peramivir.

    Interest expense was $9.2 million in 2018, compared to $8.6 million in 2017.

    Net loss for 2018 was $101.3 million, or $0.98 per share, compared to a net loss of $65.8 million, or $0.78 per share, for 2017. 

    Financial Outlook for 2019 

    BioCryst expects net operating cash use to be in the range of $105 to $130 million, and its 2019 operating expenses to be in the range of $120 to $145 million. The company’s operating expense range excludes equity-based compensation expense due to the difficulty in reliably projecting this expense, as it is impacted by the volatility and price of the company’s stock, as well as by the vesting of the company’s outstanding performance-based stock options.

    Conference Call and Webcast

    BioCryst management will host a conference call and webcast at 8:30 a.m. ET today to discuss the financial results and provide a corporate update. The live call may be accessed by dialing 877-303-8027 for domestic callers and 760-536-5165 for international callers and using conference ID # 1271286. A live webcast of the call and any slides will be available online at the investors section of the company website at www.biocryst.com. A telephone replay of the call will be available by dialing 855-859-2056 for domestic callers or 404-537-3406 for international callers and entering the conference ID# 1271286.

    About BioCryst Pharmaceuticals

    BioCryst Pharmaceuticals discovers novel, oral small-molecule medicines that treat rare diseases in which significant unmet medical needs exist and an enzyme plays a key role in the biological pathway of the disease. BioCryst has several ongoing development programs including BCX7353, an oral treatment for hereditary angioedema, BCX9930, an oral Factor D inhibitor for the treatment of complement-mediated diseases, galidesivir, a potential treatment for Marburg virus disease and Yellow Fever, and a preclinical program to develop oral ALK-2 inhibitors for the treatment of fibrodysplasia ossificans progressiva. RAPIVAB® (peramivir injection), a viral neuraminidase inhibitor for the treatment of influenza, is BioCryst's first approved product and has received regulatory approval in the U.S., Canada, Australia, Japan, Taiwan, Korea and the European Union. Post-marketing commitments for RAPIVAB are ongoing. For more information, please visit the Company's website at www.BioCryst.com.

    Forward-Looking Statements

    This press release contains forward-looking statements, including statements regarding future results, performance or achievements. These statements involve known and unknown risks, uncertainties and other factors which may cause BioCryst’s actual results, performance or achievements to be materially different from any future results, performances or achievements expressed or implied by the forward-looking statements. These statements reflect our current views with respect to future events and are based on assumptions and are subject to risks and uncertainties. Given these uncertainties, you should not place undue reliance on these forward-looking statements. Some of the factors that could affect the forward-looking statements contained herein include: that developing any HAE product candidate may take longer or may be more expensive than planned; that ongoing and future preclinical and clinical development of BCX9930, BCX9250 and our HAE second generation drug candidates (including APeX-2, APeX-S and APeX-J) may not have positive results; that BioCryst may not be able to enroll the required number of subjects in planned clinical trials of product candidates; that the company may not advance human clinical trials with product candidates as expected; that the FDA, EMA or other applicable regulatory agency may require additional studies beyond the studies planned for product candidates, or may not provide regulatory clearances which may result in delay of planned clinical trials, or may impose a clinical hold with respect to such product candidate, or withhold market approval for product candidates; that actual financial results may not be consistent with expectations, including that 2019 operating expenses and cash usage may not be within management's expected ranges. Please refer to the documents BioCryst files periodically with the Securities and Exchange Commission, specifically BioCryst’s most recent Annual Report on Form 10-K, Quarterly Reports on Form 10-Q, and Current Reports on Form 8-K, all of which identify important factors that could cause the actual results to differ materially from those contained in BioCryst’s projections and forward-looking statements.


    Contact:John Bluth+1 919 859 7910jbluth@biocryst.com

    BIOCRYST PHARMACEUTICALS, INC. CONSOLIDATED FINANCIAL SUMMARY (in thousands, except per share)                                   Statements of Operations (Unaudited)                                                                   Three Months Ended       Twelve Months Ended       December 31,       December 31,       2018       2017       2018       2017   Revenues:                               Product sales $ -     $ -     $ -     $ 1,501   Royalty revenue   1,775       3,291       6,101       10,543   Collaborative and other research and development   954       599       14,552       13,142   Total revenues   2,729       3,890       20,653       25,186                                   Expenses:           Cost of product sales   -       -       -       1,142   Research and development   23,431       16,924       84,888       66,962   General and administrative   4,490       4,698       29,514       13,933   Royalty   70       129       471       560   Total operating expenses   27,991       21,751       114,873       82,597                                   Loss from operations   (25,262 )     (17,861 )     (94,220 )     (57,411 )                                 Interest and other income   686       478       2,252       1,015   Interest expense   (2,414 )     (2,231 )     (9,176 )     (8,565 ) (Loss) gain on foreign currency derivative   (442 )     71       (108 )     (821 )                                 Net loss $ (27,432 )   $ (19,543 )   $ (101,252 )   $ (65,782 )                                 Basic and diluted net loss per common share $ (0.25 )   $ (0.20 )   $ (0.98 )   $ (0.78 )                                 Weighted average shares outstanding   109,802       98,402       103,185       84,451                                                                                                                                   Balance Sheet Data (in thousands)                                 December 31, 2018     December 31, 2017     (Unaudited)     (Note 1)   Cash, cash equivalents and investments   $  126,843           $  155,692       Restricted cash   1,544           3,286       Receivables from collaborations   4,293           6,117       Total assets   146,841           178,259       Non-recourse notes payable   29,121           28,682       Senior credit facility   29,952           23,214       Accumulated deficit   (731,969 )         (631,843 )     Stockholders’ equity   49,235           83,767       Shares of common stock outstanding   110,063           98,411                                       Note 1:  Derived from audited financial statements.                              

    Antitumor activity of CD56-chimeric antigen receptor T cells in neuroblastoma and SCLC models | killexams.com real questions and Pass4sure dumps

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    Shah MH, Lorigan P, O’Brien ME, Fossella FV, Moore KN, Bhatia S, et al. Phase I study of IMGN901, a CD56-targeting antibody-drug conjugate, in patients with CD56-positive solid tumors. Invest New Drugs. 2016;34:290–9.

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    Feng Y, Wang Y, Zhu Z, Li W, Sussman RT, Randall M, et al. Differential killing of CD56-expressing cells by drug-conjugated human antibodies targeting membrane-distal and membrane-proximal non-overlapping epitopes. MAbs. 2016;8:799–810.

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    Noble A, Giorgini A, Leggat JA. Cytokine-induced IL-10-secreting CD8 T cells represent a phenotypically distinct suppressor T-cell lineage. Blood. 2006;107:4475–83.

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    Kelly-Rogers J, Madrigal-Estebas L, O’Connor T, Doherty DG. Activation-induced expression of CD56 by T cells is associated with a reprogramming of cytolytic activity and cytokine secretion profile in vitro. Hum Immunol 2006;67:863–73.

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  • ARCA biopharma Announces Second Quarter 2018 Financial Results and Provides Corporate Update | killexams.com real questions and Pass4sure dumps

    August 09, 2018 16:15 ET | Source: ARCA biopharma, Inc.


    Dr. Bristow - Photo

    Dr. Michael Bristow, President and CEO, ARCA biopharma, Inc.

    ARCA biopharma, Inc.

    WESTMINSTER, Colo., Aug. 09, 2018 (GLOBE NEWSWIRE) -- ARCA biopharma, Inc. (Nasdaq:ABIO), a biopharmaceutical company applying a precision medicine approach to developing genetically-targeted therapies for cardiovascular diseases, today reported financial results for the quarter ended June 30, 2018.

    “The second quarter of this year saw an important milestone for the Gencaro development program with the completion of an End-of-Phase 2 FDA meeting that provided important guidance for the next steps in our development of Gencaro as potentially the first genetically-targeted treatment for atrial fibrillation,” commented Dr. Michael Bristow, ARCA’s President and Chief Executive Officer.  “With work underway on completing the Gencaro Phase 3 trial protocol and continued progress with IND enabling activities for AB171 in PAD and HF, we believe ARCA is advancing our pipeline of genetically-targeted therapeutics to address the unmet medical needs of patients with cardiovascular disease.”

    Pipeline Update

    Gencaro (bucindolol hydrochloride) - a pharmacologically unique beta-blocker and mild vasodilator being developed for the potential treatment of patients with atrial fibrillation (AF) and chronic heart failure with reduced left ventricular ejection fraction (HFrEF).

  • In April 2018, Medtronic, Inc. and ARCA agreed to extend their current U.S., Canadian and European Clinical Trial Collaboration Agreement for one additional year.
  • In May 2018, results from ARCA’s GENETIC-AF Phase 2B clinical trial were presented in a “Late Breaking Clinical Trials” oral presentation at the European Society of Cardiology (ESC) Heart Failure 2018 World Congress.
  • In June 2018, ARCA held an End-of-Phase 2 meeting with the U.S. Food and Drug Administration (FDA) to review the GENETIC-AF data and potential future Gencaro development plans.
  • FDA concurrence to proceed into Phase 3 was reached. ARCA anticipates submitting a Special Protocol Assessment (SPA) application for the proposed Gencaro Phase 3 clinical trial in the third quarter of 2018. Progress to Phase 3 is dependent on the Company receiving additional funding.
  • AB171 – a thiol-substituted isosorbide mononitrate being developed as a potential genetically-targeted treatment for heart failure (HF) and peripheral arterial disease (PAD).

  • Chemistry, manufacturing and controls (CMC) activities were continued in the second quarter.
  • IND-enabling non-clinical studies are anticipated to begin in the first half of 2019.
  • Second Quarter 2018 Summary Financial Results

    Cash, cash equivalents and marketable securities totaled $9.6 million as of June 30, 2018, compared to $11.8 million as of December 31, 2017. ARCA believes that its current cash, cash equivalents and marketable securities will be sufficient to fund its operations, at its projected cost structure, through the end of the first quarter of 2019.

    Research and development (R&D) expenses for the quarter ended June 30, 2018 totaled $1.2 million compared to $4.5 million for the corresponding period of 2017.  The $3.3 million decrease in research and development expenses in the second quarter of 2018 as compared to the second quarter 2017 was primarily due to decreased clinical expenses following the completion of the GENETIC-AF clinical trial.  The Company expects R&D expenses in 2018 to be lower than 2017 as the GENETIC-AF clinical trial has been completed.

    General and administrative (G&A) expenses for the quarter ended June 30, 2018 were $1.0 million, relatively unchanged compared to the $1.1 million in the second quarter of 2017.  ARCA expects G&A expenses in 2018 to be consistent with those in 2017 as it maintains administrative activities to support ongoing operations.

    Total operating expenses for the quarter ended June 30, 2018 were $2.2 million compared to $5.6 million for the second quarter of 2017.  The decrease in total operating expenses for the second quarter of 2018 was primarily due to the decrease in R&D expense due to the completion of the GENETIC-AF clinical trial.

    Net loss was $2.1 million, or $0.15 per share, for the second quarter of 2018 compared to $5.5 million, or $0.59 per share, for the second quarter of 2017.

    About ARCA biopharma

    ARCA biopharma is dedicated to developing genetically-targeted therapies for cardiovascular diseases through a precision medicine approach to drug development. ARCA’s lead product candidate, GencaroTM (bucindolol hydrochloride), is an investigational, pharmacologically unique beta-blocker and mild vasodilator being developed for the potential treatment of patients with atrial fibrillation (AF) and chronic heart failure with reduced left ventricular ejection fraction (HFrEF) which recently completed a Phase 2B clinical trial. ARCA has identified common genetic variations that it believes predict individual patient response to Gencaro, giving it the potential to be the first genetically-targeted AF prevention treatment. ARCA has a collaboration with Medtronic, Inc. for support of the GENETIC-AF trial. The Gencaro development program has been granted Fast Track designation by FDA. ARCA is also developing AB171, a thiol-substituted isosorbide mononitrate, as a potential genetically-targeted treatment for peripheral arterial disease (PAD) and for heart failure (HF). For more information, please visit www.arcabio.com.

    Safe Harbor Statement

    This press release contains "forward-looking statements" for purposes of the safe harbor provided by the Private Securities Litigation Reform Act of 1995. These statements include, but are not limited to, statements regarding the ability of ARCA’s financial resources to support its operations through the end of the first quarter of 2019, potential future development plans for Gencaro, the expected features and characteristics of Gencaro or AB171, including the potential for genetic variations to predict individual patient response to Gencaro, Gencaro’s potential to treat AF, AB171’s potential to treat HF, future treatment options for patients with AF, and the potential for Gencaro to be the first genetically-targeted AF prevention treatment. Such statements are based on management's current expectations and involve risks and uncertainties.  Actual results and performance could differ materially from those projected in the forward-looking statements as a result of many factors, including, without limitation, the risks and uncertainties associated with: ARCA’s financial resources and whether they will be sufficient to meet its business objectives and operational requirements; ARCA may not be able to raise sufficient capital on acceptable terms, or at all, to continue development of Gencaro or to otherwise continue operations in the future; results of earlier clinical trials may not be confirmed in future trials; the protection and market exclusivity provided by ARCA’s intellectual property; risks related to the drug discovery and the regulatory approval process; and, the impact of competitive products and technological changes.  These and other factors are identified and described in more detail in ARCA’s filings with the Securities and Exchange Commission, including without limitation ARCA’s annual report on Form 10-K for the year ended December 31, 2017, and subsequent filings. ARCA disclaims any intent or obligation to update these forward-looking statements.

    Investor & Media Contact:Derek Cole720.940.2163derek.cole@arcabio.com

    (Tables follow)

      ARCA BIOPHARMA, INC.   BALANCE SHEET DATA  (in thousands)  (unaudited)     June 30, 2018   December 31, 2017 Cash, cash equivalents & marketable securities $9,635   $11,752 Working capital $8,950   $10,229 Total assets $10,067   $12,365 Total stockholders’ equity $8,998   $10,275        


        ARCA BIOPHARMA, INC.       STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS   (unaudited)         Three Months Ended     Six Months Ended     June 30,     June 30,     2018     2017     2018     2017                                     (in thousands, except share and per share amounts)   Costs and expenses:                               Research and development $ 1,154     $ 4,508     $ 2,874     $ 7,754   General and administrative   1,002       1,051       2,055       2,186   Total costs and expenses   2,156       5,559       4,929       9,940   Loss from operations   (2,156 )     (5,559 )     (4,929 )     (9,940 )                                 Interest and other income   43       39       84       84   Interest expense   (3 )     (2 )     (6 )     (4 ) Net loss $ (2,116 )   $ (5,522 )   $ (4,851 )   $ (9,860 )                                 Change in unrealized loss on marketable securities   —       4       2       14   Comprehensive loss $ (2,116 )   $ (5,518 )   $ (4,849 )   $ (9,846 )                                 Net loss per share:                               Basic and diluted $ (0.15 )   $ (0.59 )   $ (0.35 )   $ (1.07 ) Weighted average shares outstanding:                               Basic and diluted   13,923,512       9,324,822       13,772,947       9,210,186                                  

    A photo accompanying this announcement is available at http://www.globenewswire.com/NewsRoom/AttachmentNg/af496e97-20da-420a-bf93-e51b3a3ed740

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